Document Detail


Functional outcome after delivery of intrathecal baclofen.
MedLine Citation:
PMID:  2916915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with multiple sclerosis or spinal cord injury often have severe, disabling spasticity. This is frequently treated with oral medications or with destructive neurosurgical procedures. We report on a group of patients with spasticity not relieved by these methods. These patients were subsequently treated with intrathecal baclofen delivered by an implanted programmable drug pump. Twenty-one patients have received this form of treatment, and the functional status of eight has been tracked by the Patient Evaluation Conference System (PECS) for at least six months. In most cases, spasticity, performance of bowel and bladder programs, and performance of ADL improved after delivery of intrathecal baclofen. The improvements appear to be due to the decrease in hypertonicity and the increased ease of movement (passive or active) in affected extremities. Intrathecal baclofen should be considered as a treatment method in patients with severe spasticity of spinal origin.
Authors:
B Parke; R D Penn; S M Savoy; D Corcos
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  70     ISSN:  0003-9993     ISO Abbreviation:  Arch Phys Med Rehabil     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-03-15     Completed Date:  1989-03-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  30-2     Citation Subset:  AIM; IM    
Affiliation:
Department of Rehabilitation Medicine, Rush Medical College, Chicago, IL 60612.
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MeSH Terms
Descriptor/Qualifier:
Activities of Daily Living
Adult
Baclofen / administration & dosage*
Female
Humans
Injections, Spinal
Male
Middle Aged
Multiple Sclerosis / complications
Muscle Spasticity / drug therapy*,  etiology,  physiopathology
Prospective Studies
Spinal Cord Injuries / complications
Grant Support
ID/Acronym/Agency:
FD-R-000204-02/FD/FDA HHS; NS15630-09/NS/NINDS NIH HHS; NS23593/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
1134-47-0/Baclofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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