Document Detail


Functional organization within the medullary reticular formation of the intact unanesthetized cat. III. Microstimulation during locomotion.
MedLine Citation:
PMID:  1753295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. This article presents the results from stimulation in 21 loci within the medullary reticular formation (MRF; between 0.5 and 2.5 mm from the midline) and in 5 loci in the medial longitudinal fasciculus (MLF) of four intact, unanesthetized cats during locomotion. Stimulus trains (11 pulses, 0.2-ms duration, 330 Hz, stimulus strength 35 microA) were applied at those loci in each track at which the most widespread effects in each of the four limbs were obtained with the cat at rest. Electromyograms were recorded from flexor and extensor muscles of each limb. 2. As previously reported, stimulation with the cat at rest generally evoked brief, short-latency, twitch responses in both flexor and extensor muscles of more than one limb. In contrast, stimulation during locomotion evoked a more complex pattern of activity in which responses were normally evoked in one or other of the muscle pairs and incorporated into the locomotor pattern. 3. In the majority of sites, the stimulation evoked excitatory responses in the flexor muscles of each of the four limbs during that period of the step cycle in which each respective muscle was naturally active; stimulation in the stance phase of locomotion, although less effective, was also capable of producing responses in these muscles. All three ipsilateral extensor muscles studied [long and lateral heads of triceps and vastus lateralis (Tri, TriL, and VL, respectively)] were normally inhibited during their phase of muscle activity, although excitatory responses were occasionally seen. Responses in the contralateral (co) Tri were invariably excitatory and were largest during the period of muscle activity, whereas responses during the period of activity of the coVL were mixed, with both excitatory and inhibitory responses being seen from any one locus. 4. Excitatory responses were normally largest when stimulation was applied during the time that the muscle was active during the locomotor cycle. Responses evoked at times when the muscle was inactive were sometimes larger than those evoked with the animal at rest; such responses were most commonly seen in the hindlimb flexors and in the coVL. 5. In both flexors and extensors of each of the four limbs, the latency of the responses was greatest when the cat was at rest and least for stimuli given during the period of activity of the respective muscle. Average latencies during the period of muscle activity ranged from a minimum of 9.0 +/- 2.6 (SD) ms for inhibitory responses in the ipsilateral Tri and TriL to a maximum of 17.1 +/- 3.0 ms for the responses evoked in the ipsilateral semitendinosus.(ABSTRACT TRUNCATED AT 400 WORDS)
Authors:
T Drew
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurophysiology     Volume:  66     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-01-30     Completed Date:  1992-01-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  919-38     Citation Subset:  IM    
Affiliation:
Département de Physiologie, Faculté de Médecine, Université de Montréal, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Axons / physiology
Brain Stem / physiology
Cats
Decerebrate State
Electric Stimulation
Electromyography
Evoked Potentials / physiology
Forelimb / physiology
Hindlimb / physiology
Humans
Infant, Newborn
Locomotion / physiology*
Medulla Oblongata / physiology*
Motor Neurons / physiology
Muscles / physiology
Reaction Time
Reticular Formation / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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