Document Detail

Functional ontogeny of the proglucagon-derived peptide axis in the premature human neonate.
MedLine Citation:
PMID:  18166537     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The regulation of intestinal growth and development in human neonates is incompletely understood, which hinders the provision of nutrients enterally. The "hindgut" hormones glucagon-like peptides 1 and 2 have been shown to play an important role in the regulation of nutrient assimilation, intestinal growth, and function. OBJECTIVE: Our goal was to investigate the production of glucagon-like peptides 1 and 2 in premature human infants and examine the effects of prematurity and feeding on hormone release. PATIENTS AND METHODS: With informed consent, premature infants who were admitted to a tertiary neonatal intensive care nursery (gestational age: 28-32 weeks) were monitored with weekly determinations of postprandial glucagon-like peptide 1 and 2 levels. Comparison studies with groups of normal infants and adults were performed. Hormone levels were obtained by using specific radioimmunoassay for glucagon-like peptide 1 (1-36) and glucagon-like peptide 2 (1-33), modified for small sample volumes; accurate monitoring of enteral intake was performed at all of the sampling time points. RESULTS: Forty-five infants with a mean gestational age of 29.6 +/- 1.9 weeks were studied; fasting levels of both glucagon-like peptides 1 and 2 were elevated. There was no correlation between gestational age and glucagon-like peptide 2 output. However, both glucagon-like peptide 1 and 2 levels were correlated with the caloric value of feeds. CONCLUSIONS: The premature human neonate has significantly higher fasting levels of glucagon-like peptides 1 and 2 compared with adults; feeding increases these levels further. These findings suggest that the proglucagon-derived peptides may have a role in normal intestinal development and nutrient handling.
Harish Amin; Jens J Holst; Bolette Hartmann; Laurie Wallace; Jim Wright; David L Sigalet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics     Volume:  121     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-01     Completed Date:  2008-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e180-6     Citation Subset:  AIM; IM    
Department of Neonatology, Foothills Hospital, Calgary, Alberta, Canada.
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MeSH Terms
Age Factors
Biological Markers / blood
Case-Control Studies
Cohort Studies
Energy Metabolism
Follow-Up Studies
Gastrointestinal Tract / embryology,  metabolism*
Gestational Age
Glucagon-Like Peptide 1 / blood
Glucagon-Like Peptide 2 / blood
Glucagon-Like Peptides / blood*
Infant Food
Infant, Newborn
Infant, Premature / blood*
Intensive Care Units, Neonatal
Intestinal Absorption / physiology*
Reference Values
Risk Factors
Reg. No./Substance:
0/Biological Markers; 0/Glucagon-Like Peptide 2; 62340-29-8/Glucagon-Like Peptides; 89750-14-1/Glucagon-Like Peptide 1

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