| Functional mitral regurgitation predicts 1-year mortality in elderly patients with systolic chronic heart failure. | |
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MedLine Citation:
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PMID: 15919238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIM: Mitral regurgitation (MR) has been demonstrated to be a powerful predictor of adverse outcome in middle-aged patients with chronic heart failure (CHF). In this study, we sought to define the prognostic impact of functional mitral regurgitation in a population of elderly patients with systolic CHF. METHODS: One hundred seventy-five outpatients aged >70 years with validated CHF and left ventricular ejection fraction <40% underwent clinical and echocardiographic evaluations at baseline. Mitral regurgitation was diagnosed by Color Doppler and quantified in 5 categorical values using a 0-4+ grading system. Outcome measures included 1-year mortality and hospitalization for worsening CHF. RESULTS: The distribution of patients according to the 5 different degrees of MR detected at baseline was: absent=11%, 1+=31%, 2+=38%, 3+=16%, 4+=4%. The relationship between MR and mortality was direct and approximately linear (r=0.39, p=0.00001). The prevalence of death in the 5 subgroups was 0%, 7%, 15%, 45%, 57%, respectively. Multivariate logistic regression analysis showed that MR was the strongest predictor of death (OR 4.47, 95% CI 1.50-13.0), independently of the presence of diabetes mellitus, older age and larger left ventricular end-diastolic volume. No association was found between MR and hospitalization for worsening CHF (r=0.08, p=0.41). CONCLUSIONS: This study establishes the direct and independent relationship between MR severity and one-year mortality among elders with systolic CHF. Conversely, MR does not provide useful information regarding the risk of subsequent hospitalization for worsening CHF. |
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Authors:
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Giovanni Cioffi; Luigi Tarantini; Stefania De Feo; Giovanni Pulignano; Donatella Del Sindaco; Carlo Stefenelli; Andrea Di Lenarda; Cristina Opasich |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of heart failure Volume: 7 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-05 Completed Date: 2006-03-07 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1112-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Villa Bianca Hospital, Trento, Italy. gcioffi@villabiancatrento.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Disease Progression Echocardiography, Doppler, Color Female Follow-Up Studies Heart Failure / complications, mortality*, physiopathology Humans Male Mitral Valve Insufficiency / complications*, physiopathology, ultrasonography Prognosis Retrospective Studies Stroke Volume / physiology Survival Rate |
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