| Functional microdomains in bacterial membranes. | |
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MedLine Citation:
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PMID: 20713508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The membranes of eukaryotic cells harbor microdomains known as lipid rafts that contain a variety of signaling and transport proteins. Here we show that bacterial membranes contain microdomains functionally similar to those of eukaryotic cells. These membrane microdomains from diverse bacteria harbor homologs of Flotillin-1, a eukaryotic protein found exclusively in lipid rafts, along with proteins involved in signaling and transport. Inhibition of lipid raft formation through the action of zaragozic acid--a known inhibitor of squalene synthases--impaired biofilm formation and protein secretion but not cell viability. The orchestration of physiological processes in microdomains may be a more widespread feature of membranes than previously appreciated. |
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Authors:
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Daniel López; Roberto Kolter |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-08-16 |
Journal Detail:
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Title: Genes & development Volume: 24 ISSN: 1549-5477 ISO Abbreviation: Genes Dev. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-02 Completed Date: 2010-09-14 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 8711660 Medline TA: Genes Dev Country: United States |
Other Details:
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Languages: eng Pagination: 1893-902 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacillus subtilis
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enzymology,
metabolism Bacteria / enzymology, metabolism* Bacterial Proteins / metabolism* Biofilms / drug effects Enzyme Inhibitors / metabolism Farnesyl-Diphosphate Farnesyltransferase / metabolism Membrane Microdomains / metabolism* Membrane Proteins / metabolism Protein Transport Signal Transduction / drug effects Sugar Alcohol Dehydrogenases / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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GM58213/GM/NIGMS NIH HHS; R01 GM058213-14/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Enzyme Inhibitors; 0/Membrane Proteins; 0/flotillins; EC 1.1.-/IolX protein, Bacillus subtilis; EC 1.1.-/Sugar Alcohol Dehydrogenases; EC 2.5.1.21/Farnesyl-Diphosphate Farnesyltransferase |
| Comments/Corrections | |
Comment In:
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Nat Rev Microbiol. 2010 Nov;8(11):756
[PMID:
21080545
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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