| Functional metal ions in nucleic acids. | |
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MedLine Citation:
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PMID: 21072378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Metal ions are inevitably involved in almost every aspect of nucleic acid chemistry. Their most prominent role is certainly the maintenance of nucleic acid structural integrity. However, they serve various other roles as well, e.g. as catalytic co-factors in ribozymes, in determining the secondary structure of tetra-stranded helices, during RNA folding, and possibly even in enabling nucleobase-centred acid/base catalysis under physiological conditions and in modulating homogeneous genetic recombination. This tutorial review gives a compact overview of the multifaceted situations in which metal ions exert specific functions in nucleic acids, also including a discussion of structural metal ions in regular DNA and RNA as well as triple helices, guanine quadruplexes, and helical junctions. It has a strong focus on metal ions that are naturally present in living systems and only occasionally includes a description of the interaction of exogenous metal complexes with nucleic acids (or their components), provided that the results of these studies can be transferred into the context of endogenous metal ions. |
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Authors:
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Jens Müller |
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Publication Detail:
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Type: Journal Article Date: 2010-03-18 |
Journal Detail:
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Title: Metallomics : integrated biometal science Volume: 2 ISSN: 1756-591X ISO Abbreviation: Metallomics Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-11-12 Completed Date: 2011-02-22 Revised Date: 2011-09-16 |
Medline Journal Info:
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Nlm Unique ID: 101478346 Medline TA: Metallomics Country: England |
Other Details:
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Languages: eng Pagination: 318-27 Citation Subset: IM |
Affiliation:
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Westfälische Wilhelms-Universität Münster, Institut für Anorganische und Analytische Chemie, Corrensstr. 28/30, 48149 Münster, Germany. mueller.j@uni-muenster.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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DNA
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chemistry Humans Metals / chemistry* Models, Molecular Nucleic Acid Conformation* Nucleic Acids / chemistry* RNA / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Metals; 0/Nucleic Acids; 63231-63-0/RNA; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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