Document Detail

Functional and metabolic effects of uridine and UTP on the skeletal muscle of the rat submitted to exercise.
MedLine Citation:
PMID:  1713506     Owner:  NLM     Status:  MEDLINE    
Twenty millimolar and 2 mM uridine triphosphate and 2 mM uridine were injected intra-arterially into rat leg muscles during a 20 min period of intense exercise and during the recovery phase (20 min). Administration of 20 mM uridine triphosphate during exercise, provoked a complete depression of muscle contractility. On the contrary, supply of 2 mM uridine triphosphate or 20 mM uridine induced a reduction in the decrease of muscular developed tension during the exercise period of time and favoured functional recovery. This positive effect of pyrimidine compounds on muscular functional parameters did not seem to be correlated with metabolic effects. Indeed, 2 mM uridine supply did not modify the evolution of intramuscular glycogen and lactate concentrations and made worsened the adenine nucleotide degradation induced by exercise.
J Aussedat; D Laurent; M Tonguino; A Rossi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives internationales de physiologie, de biochimie et de biophysique     Volume:  99     ISSN:  0778-3124     ISO Abbreviation:  Arch Int Physiol Biochim Biophys     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-08-30     Completed Date:  1991-08-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9111069     Medline TA:  Arch Int Physiol Biochim Biophys     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  195-8     Citation Subset:  IM    
Laboratoire de Physiologie Cellulaire Cardiaque, URA CNRS, Grenoble, France.
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MeSH Terms
Energy Metabolism / drug effects*
Muscle Contraction / drug effects*
Physical Exertion / physiology*
Rats, Inbred Strains
Uridine / pharmacology*
Uridine Triphosphate / pharmacology*
Reg. No./Substance:
58-96-8/Uridine; 63-39-8/Uridine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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