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Functional magnetic resonance imaging study reveals differences in the habituation to psychological stress in patients with Crohn's disease versus healthy controls.
MedLine Citation:
PMID:  22752251     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In patients with Crohn's disease (CD) stress is believed to increase the incidence of disease relapse. The brain processes stressful stimuli and triggers the stress-evoked responses. Habituation to stress is an adaptive process that allows minimizing these responses. We hypothesized inadequate habituation to stress in CD patients. The aim of this study was to compare the neural habituation between CD patients and controls. Twenty CD patients and eighteen controls underwent a functional magnetic resonance imaging while performing two repeated runs of a stress-evoking task. The task elicited different neural activity between the groups across runs in (1) amygdala, hippocampus, (2) insula, putamen (3) cerebellar regions, suggesting altered habituation to stress in patients. These structures regulate the neuroendocrine and autonomic stress-evoked responses that control the proinflammatory responses. The inadequate habituation to stress that we found in patients could play a role in the relationship between stress and inflammatory exacerbations in CD.
Authors:
Alessandro Agostini; Nicola Filippini; Francesca Benuzzi; Angela Bertani; Antonella Scarcelli; Chiara Leoni; Valentina Farinelli; Donatella Riso; Rosy Tambasco; Carlo Calabrese; Fernando Rizzello; Paolo Gionchetti; Mauro Ercolani; Paolo Nichelli; Massimo Campieri
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-3
Journal Detail:
Title:  Journal of behavioral medicine     Volume:  -     ISSN:  1573-3521     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7807105     Medline TA:  J Behav Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Psychology, University of Bologna, Bologna, Italy, alessandro.furey@tiscali.it.
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