| Functional magnetic resonance imaging evidence for abnormalities in response selection in attention deficit hyperactivity disorder: differences in activation associated with response inhibition but not habitual motor response. | |
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MedLine Citation:
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PMID: 18004945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Impaired response inhibition is thought to be a core deficit in attention deficit hyperactivity disorder (ADHD). Prior imaging studies investigating response inhibition in children with ADHD have used tasks involving different cognitive resources, thereby complicating the interpretation of their findings. In this study, a classical go/no-go task with a well-ingrained stimulus-response association (green = go; red = no-go) was used in order to minimize extraneous cognitive demands. Twenty-five children with ADHD and 25 typically developing (TD) children between the ages of 8 and 13 years and group-matched for IQ and performance on the go/no-go task were studied using event-related functional magnetic resonance imaging (fMRI). Analyses were used to examine differences in activation between the ADHD and TD groups for "go" (habitual motor response) and "no-go" (requiring inhibition of the motor response) events. Region-of-interest analyses revealed no between-group difference in activation in association with "go" events. For "no-go" events, the children with ADHD demonstrated significantly less activation than did TD controls within a network important for inhibiting a motor response to a visual stimulus, with frontal differences localized to the pre-supplementary motor area. Although blood oxygenation level-dependent fMRI data show no differences between children with ADHD and TD children in association with a habituated motor "go" response, during "no-go" events, which require selecting not to respond, children with ADHD show diminished recruitment of networks important for response inhibition. The findings suggest that abnormalities in circuits important for motor response selection contribute to deficits in response inhibition in children with ADHD and lend support to the growing awareness of ADHD-associated anomalies in medial frontal regions important for the control of voluntary actions. |
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Authors:
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Stacy J Suskauer; Daniel J Simmonds; Sunaina Fotedar; Joanna G Blankner; James J Pekar; Martha B Denckla; Stewart H Mostofsky |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cognitive neuroscience Volume: 20 ISSN: 0898-929X ISO Abbreviation: J Cogn Neurosci Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-13 Completed Date: 2008-07-02 Revised Date: 2013-04-09 |
Medline Journal Info:
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Nlm Unique ID: 8910747 Medline TA: J Cogn Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 478-93 Citation Subset: IM |
Affiliation:
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Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Attention Deficit Disorder with Hyperactivity / physiopathology* Brain Mapping Case-Control Studies Cerebral Cortex / blood supply*, physiopathology* Child Decision Making / physiology* Female Humans Image Processing, Computer-Assisted / methods Inhibition (Psychology)* Magnetic Resonance Imaging* Male Neuropsychological Tests Oxygen / blood Reaction Time / physiology |
| Grant Support | |
ID/Acronym/Agency:
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K02 NS044850-03/NS/NINDS NIH HHS; M01 RR000052-38S10624/RR/NCRR NIH HHS; R01 MH078160/MH/NIMH NIH HHS; R01 MH085328/MH/NIMH NIH HHS; R01 NS047781-02/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
| Comments/Corrections | |
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