Document Detail


Functional linear discriminant analysis: a new longitudinal approach to the assessment of embryonic growth.
MedLine Citation:
PMID:  18978027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Functional linear discriminant analysis (FLDA) is a new growth assessment technique using serial measurements to discriminate between normal and abnormal fetal growth. We used FLDA to assess and compare growth in live pregnancies destined to miscarry with those remaining viable. METHODS: This was a prospective cohort study of women with ultrasound scans on at least two separate occasions showing live pregnancies. Serial crown-rump length (CRL), mean gestational sac diameter and mean yolk sac diameter measurements were recorded. The ability of FLDA to predict subsequent miscarriage was compared with that of a single CRL measurement. RESULTS: Of 521 included pregnancies, 493 (94.6%) remained viable at 14 weeks and 28 (5.4%) miscarried. The CRL growth rate was significantly lower in those that miscarried (one-sample t-test, P = 2.638E-22). The sensitivity of FLDA in predicting miscarriage from serial CRL measurements was 60.7% and specificity was 93.1% [positive predictive value (PPV) 33.3%, negative predictive value (NPV) 97.7%]. This was significantly better for predicting miscarriage than a single CRL observation of more than 2SD below that expected (sensitivity 53.6%, specificity 72.2%, PPV 9.9%, NPV 96.5%). CONCLUSIONS: FLDA discriminates between normal and abnormal growth to predict miscarriage with high specificity. FLDA predicts miscarriage better than a single observation of a small CRL.
Authors:
C Bottomley; A Daemen; F Mukri; A T Papageorghiou; E Kirk; A Pexsters; B De Moor; D Timmerman; T Bourne
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Publication Detail:
Type:  Journal Article; Validation Studies     Date:  2008-10-31
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  24     ISSN:  1460-2350     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  278-83     Citation Subset:  IM    
Affiliation:
Early Pregnancy and Gynaecology Ultrasound Unit, Department of Obstetrics and Gynaecology, St George's University of London, Third Floor Lanesborough Wing, Cranmer Terrace, London SW17 0RE, UK. ceciliabottomley@doctors.org.uk
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / ultrasonography*
Crown-Rump Length
Embryonic Development*
Female
Humans
Longitudinal Studies
Pregnancy
Sensitivity and Specificity
Ultrasonography, Prenatal / methods*
Yolk Sac / ultrasonography

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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