Document Detail


Functional lateralization of sensorimotor cortex in infants measured using multi-channel near-infrared spectroscopy.
MedLine Citation:
PMID:  21283052     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Multi-channel near-infrared spectroscopy (MNIRS) was used for the functional imaging of the sensorimotor cortex of newborn infants during passive knee and elbow movement under sedated sleep. Contralateral knee and elbow movement caused a marked increase in the concentration of oxyhemoglobin ([oxyHb]) from the baseline values at site within the sensorimotor area in all infants. During ipsilateral knee and elbow movement, [oxyHb] showed smaller changes, equivalent to 64 ± 23 and 66 ± 28% of the changes that occurred with contralateral stimulation, respectively. The mean times corresponding to maximal changes in [oxyHb] were 16.1 ± 3.3 sec for contralateral knee movement, and 17.9 ± 5.7 sec for contralateral elbow movement. No significant difference was noted between the mean latencies showing the maximal changes in [oxyHb] between contralateral and ipsilateral movement. There was a significant difference in the area and degree of response between the contralateral and ipsilateral movement. MNIRS could be a useful tool to understand the pathophysiology of the developing brain and monitor cortical responses in various clinical situations. ABBREVIATIONS::
Authors:
Takashi Kusaka; Kenichi Isobe; Takanori Miki; Masaki Ueno; Kosuke Koyano; Shinji Nakamura; Makoto Nakamura; Yukihiko Konishi; Toru Kuboi; Ikuko Kato; Kensuke Okubo; Saneyuki Yasuda; Tomoko Nishida; Susumu Itoh
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-28
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-2-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Maternal Perinatal Center [T.Kus., K.K., S.Y.], Department of Pediatrics [K.I., S.N., M.N., Y.K., T.Kub., I.K., K.O., S.I.], Department of Anatomy and Neurobiology [T.M.], Departments of Pathology and Host Defense [M.U.], Kagawa University, Kitagun, Kagawa 761-0793, Japan; Department of Education for Children with Special Needs [T.N.], Kagawa University, Takamatsu City, Kagawa 760-8522, Japan.
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