| Functional lactide monomers: methodology and polymerization. | |
| | |
MedLine Citation:
|
PMID: 16768392 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Side-chain-functionalized lactide analogues have been synthesized from commercially available amino acids and polymerized using stannous octoate as a catalyst. The synthetic strategy presented allows for the incorporation of any protected amino acid for the preparation of functionalized diastereomerically pure lactide monomers. The resulting functionalized cyclic monomers can be homopolymerized and copolymerized with lactides and then quantitatively deprotected forming new functional poly(lactide)-based materials. This strategy allows for the introduction of functional groups along a poly(lactide) (PLA) backbone that after deprotection can be viewed as chemical handles for further functionalization of PLA, yielding improved biomaterials for a variety of applications. |
| | |
Authors:
|
Warren W Gerhardt; David E Noga; Kenneth I Hardcastle; Andrés J García; David M Collard; Marcus Weck |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Biomacromolecules Volume: 7 ISSN: 1525-7797 ISO Abbreviation: Biomacromolecules Publication Date: 2006 Jun |
Date Detail:
|
Created Date: 2006-06-13 Completed Date: 2006-11-08 Revised Date: 2010-09-16 |
Medline Journal Info:
|
Nlm Unique ID: 100892849 Medline TA: Biomacromolecules Country: United States |
Other Details:
|
Languages: eng Pagination: 1735-42 Citation Subset: IM |
Affiliation:
|
School of Chemistry and Biochemistry and Woodruff School of Mechanical Engineering and Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acids
/
chemistry Catalysis Crystallography, X-Ray Hexanoic Acids / chemistry Lactic Acid / analogs & derivatives, chemical synthesis*, chemistry Models, Molecular Molecular Structure Stereoisomerism |
| Grant Support | |
ID/Acronym/Agency:
|
R21 EB004589-01A1/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/2-ethylhexanoic acid tin(II) salt; 0/Amino Acids; 0/Hexanoic Acids; 50-21-5/Lactic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Thermogelling aqueous solutions of alternating multiblock copolymers of poly(L-lactic acid) and poly...
Next Document: The FDAM method: determination of carboxyl profiles in cellulosic materials by combining group-selec...