Document Detail

Functional interpretation of the kidney juxtaglomerular apparatus using renin immunohistochemistry in Bartter's, pseudo-Bartter's and Conn's syndromes.
MedLine Citation:
PMID:  2130539     Owner:  NLM     Status:  MEDLINE    
A comparative study of renin immunoreactivity in the juxtaglomerular apparatus of the human kidney was performed using the indirect immunoperoxidase method on a random microscopic sections. In renal biopsies taken from a case of Bartter's syndrome and a case of pseudo-Bartter's syndrome, the number of renin-positive juxtaglomerular apparatus (JGA) and the number of renin-positive cells in each JGA were significantly greater than in five renal specimens from control autopsy cases. In Conn's syndrome, none of the glomeruli contained renin-immunoreactive JGA. The number of renin-positive cells/mm2 in the renal cortex in cases of Bartter's and pseudo-Bartter's syndromes were 17.5 and 20.3, respectively, while in the control group, the range was 0.78-1.77 (mean 1.08). Together with other histochemical findings routinely examined in renal specimens, renin immunohistochemistry on random sections may be helpful in diagnostic renal pathology.
N Lertprasertsuke; K Kakudo; Y Osamura; Y Nomoto; H Sakai; K Watanabe
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Tokai journal of experimental and clinical medicine     Volume:  15     ISSN:  0385-0005     ISO Abbreviation:  Tokai J. Exp. Clin. Med.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1991-11-14     Completed Date:  1991-11-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704186     Medline TA:  Tokai J Exp Clin Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  317-26     Citation Subset:  IM    
Department of Pathology, School of Medicine, Tokai University, Kanagawa, Japan.
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MeSH Terms
Bartter Syndrome / metabolism,  pathology,  physiopathology*
Hyperaldosteronism / metabolism,  pathology,  physiopathology*
Juxtaglomerular Apparatus / chemistry,  physiopathology*,  ultrastructure
Microscopy, Electron
Microscopy, Immunoelectron
Middle Aged
Renin / analysis*
Reg. No./Substance:

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