Document Detail


Functional intermediates in reaction of cytochrome oxidase with oxygen.
MedLine Citation:
PMID:  165519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of a low temperature kinetic method for the flash photolysis of the compounds of membrane-bound cytochrome a3 with carbon monoxide in the presence of oxygen affords evidence for three categories of functional intermediate compounds of cytochrome a3 and oxygen. The three classes are identified as follows: Compounds of Type A are considered to be "oxy" compounds of the ferrous heme. They have the composition a3-2+. O2. Compounds of Type B are considered to be peroxide compounds (CU-2+A3-3+ O-2= or CU-2+A3-3+ O2H2) or the equivalent heme Fe-Cu peroxide bridge structures. Compounds of Type C are formed from the ferricyanide pretreated oxidase and may involve higher oxidation states of the heme iron such as quadrivalent iron, and peroxide. Kinetic and equilibrium studies show these compounds to be functional in oxygen reduction in the sequence A yields B yield cytochromes a, c, c1, etc.
Authors:
B Chance; C Saronio; J S Leigh
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  72     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1975-08-04     Completed Date:  1975-08-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1635-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Binding Sites
Calorimetry
Columbidae
Copper / analysis
Electron Transport Complex IV* / metabolism
Iron / analysis
Kinetics
Mitochondria, Muscle / enzymology
Myocardium
Oxygen*
Photochemistry
Protein Binding
Spectrophotometry
Temperature
Thermodynamics
Chemical
Reg. No./Substance:
7439-89-6/Iron; 7440-50-8/Copper; 7782-44-7/Oxygen; EC 1.9.3.1/Electron Transport Complex IV
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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