Document Detail


Functional interferences in host inflammatory immune response by airway allergic inflammation restrain experimental periodontitis development in mice.
MedLine Citation:
PMID:  21143491     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
AIMS: periodontal disease (PD) and airway allergic inflammation (AL) present opposing inflammatory immunological features and clinically present an inverse correlation. However, the putative mechanisms underlying such opposite association are unknown.
MATERIAL AND METHODS: Balb/C mice were submitted to the co-induction of experimental PD (induced by Actinobacillus actinomycetemcomitans oral inoculation) and AL [induced by sensitization with ovalbumin (OVA) and the subsequent OVA challenges], and evaluated regarding PD and AL severity, immune response [cytokine production at periodontal tissues, and T-helper transcription factors in submandibular lymph nodes (LNs)] and infection parameters.
RESULTS: PD/AL co-induction decreased PD alveolar bone loss and periodontal inflammation while experimental AL parameters were unaltered. An active functional interference was verified, because independent OVA sensitization and challenge not modulate PD outcome. PD+AL group presented decreased tumour necrosis factor-α (TNF-α), interleukin (IL)-1β, interferon-γ, IL-17A, receptor activator of nuclear factor κ-light-chain-enhancer of activated B cells ligand and matrix metalloproteinase (MMP)-13 levels in periodontal tissues, while IL-4 and IL-10 levels were unaltered by AL co-induction. AL co-induction also resulted in upregulated T-bet and related orphan receptor γ and downregulated GATA3 levels expression in submandibular LNs when compared with PD group.
CONCLUSION: our results demonstrate that the interaction between experimental periodontitis and allergy involves functional immunological interferences, which restrains experimental periodontitis development by means of a skewed immune response.
Authors:
Denise Morais da Fonseca; Ana Paula Fávaro Trombone; Carlos Eduardo Repeke; Mario Julio Avila-Campos; Arlete A M Coelho-Castelo; João Santana Silva; Ana Paula Campanelli; Vânia Luiza Deperon Bonato; Gustavo Pompermaier Garlet
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-09
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  38     ISSN:  1600-051X     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  131-41     Citation Subset:  D; IM    
Affiliation:
Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto - FMRP/USP, Ribeirão Preto, SP, Brazil.
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