Document Detail

Functional integrity and aging of the left internal thoracic artery after coronary artery bypass surgery.
MedLine Citation:
PMID:  10917948     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the endothelial function in the left internal thoracic artery after coronary artery bypass surgery and to identify predictors of early dysfunction, we performed a provocative test with acetylcholine in 23 male patients who underwent routine postoperative coronary angiography. METHODS: The change in mean diameter of the proximal thoracic artery was assessed by quantitative angiography after selective injections of acetylcholine and nitroglycerin. RESULTS: The thoracic artery showed a 6.8% (P <. 001) and 9.0% (P <.001) increase in mean diameter after acetylcholine and nitroglycerin administration, respectively. Vasodilative responses to acetylcholine and nitroglycerin administration were strongly correlated (R: 0.88; P <.001). Among the common risk factors, only age was associated with an impairment in the vasodilative response of the arterial graft (P =.001), and acetylcholine-induced vasodilation was inversely correlated to the age of the patient (R: 0.69; P <.001). CONCLUSIONS: Endothelium-dependent vasodilative response to acetylcholine administration seems well preserved in the left internal thoracic artery after surgery. Common risk factors, except for age, do not affect the functional integrity of the arterial graft. The vasodilative properties of the graft depend on the age of the patient and do not deteriorate over time after operation.
G Amoroso; R A Tio; M A Mariani; A J Van Boven; G A Jessurun; S H Monnink; J G Grandjean; P W Boonstra; H J Crijns
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  120     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-08-30     Completed Date:  2000-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  313-8     Citation Subset:  AIM; IM    
Department of Cardiology and Department of Cardiothoracic Surgery, Thoraxcenter, University Hospital of Groningen, The Netherlands.
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MeSH Terms
Acetylcholine / administration & dosage
Age Factors
Coronary Angiography
Coronary Artery Bypass*
Endothelium, Vascular / drug effects,  physiology
Mammary Arteries / drug effects*,  physiology*
Middle Aged
Nitroglycerin / administration & dosage
Prospective Studies
Regression Analysis
Risk Factors
Treatment Outcome
Vasodilator Agents / administration & dosage
Reg. No./Substance:
0/Vasodilator Agents; 51-84-3/Acetylcholine; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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