Document Detail

Functional impairment in peripheral artery disease and how to improve it in 2013.
MedLine Citation:
PMID:  23420443     Owner:  NLM     Status:  MEDLINE    
Lower extremity peripheral artery disease (PAD) affects 8 million men and women in the United States and will be increasingly common as the U.S. population lives longer with chronic disease. People with PAD have poorer walking endurance, slower walking velocity, and poorer balance, compared with individuals without PAD. People with PAD may reduce their walking activity to avoid leg symptoms. Thus, clinicians should not equate stabilization or improvement in exertional leg symptoms with stabilization or improvement in walking performance in PAD. In addition, even asymptomatic PAD patients have greater functional impairment and faster functional decline than individuals without PAD. Of the 2 FDA-approved medications for treating claudication symptoms, pentoxifylline may not be more efficacious than placebo, whereas cilostazol confers a modest improvement in treadmill walking performance. Supervised treadmill walking exercise is associated with substantial improvement in walking endurance, but many PAD patients do not have access to supervised exercise programs. Unsupervised walking exercise programs may be beneficial in PAD, but data are mixed.
Mary McGrae McDermott
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current cardiology reports     Volume:  15     ISSN:  1534-3170     ISO Abbreviation:  Curr Cardiol Rep     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-02-19     Completed Date:  2013-07-23     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  347     Citation Subset:  IM    
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MeSH Terms
Disease Progression
Exercise Therapy / methods
Intermittent Claudication / etiology,  therapy
Lower Extremity / blood supply*
Motor Activity / physiology
Peripheral Arterial Disease / complications,  physiopathology*,  therapy*
Walking / physiology
Grant Support

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