Document Detail

Functional impairment of the arterial wall in primary Sj?gren's syndrome: combined action of immunologic and inflammatory factors.
MedLine Citation:
PMID:  20191479     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Primary Sj?gren's syndrome (SS) shares clinical and serologic features with rheumatoid arthritis and systemic lupus erythematosus, 2 diseases characterized by acceleration of atherosclerosis. Signs of precocious atherosclerosis have also been shown in SS, although the pathogenic basis of early arterial damage is unclear. The arterial wall was functionally evaluated in SS subjects with analysis of the role played by disease-related factors. METHODS: Endothelium-dependent flow-mediated vasodilation (FMV) and endothelium-independent nitrate-mediated vasodilation (NMV) were evaluated in 45 women with SS and 59 age-matched female controls. In addition, serum soluble intercellular adhesion molecule 1, soluble vascular cell adhesion molecule 1 (VCAM-1), and nitrotyrosine were detected. RESULTS: Although patient FMV values did not differ from those of control subjects (mean +/- SD 7.4 +/- 3.6 versus 7.7 +/- 1.9; not significant), NMV was lower in SS patients than in controls (mean +/- SD 8.1 +/- 3.5 versus 10.3 +/- 2.1; P </= 0.001). Patient NMV was inversely correlated with soluble VCAM-1 levels (r = -0.38, P = 0.001) and directly correlated with leukocyte count (r = 0.26, P = 0.03). An NMV decrease was confirmed in SS patient subsets with evidence of leukopenia, rheumatoid factor, anti-SSB antibodies, and joint involvement. However, patients with joint involvement or parotid enlargement, 2 of the sites mainly affected by chronic inflammation in SS, had an FMV lower than controls and patients without these clinical features. CONCLUSION: Our results suggest that a functional impairment of the arterial wall may sustain early phases of atherosclerotic damage in SS. A combined effect of disease-related chronic inflammatory and immunologic factors appears to support dysfunction of endothelium and vascular smooth muscle cells, respectively.
Roberto Gerli; Gaetano Vaudo; Elena Bartoloni Bocci; Giuseppe Schillaci; Alessia Alunno; Filippo Luccioli; Raed Hijazi; Elmo Mannarino; Yehuda Shoenfeld
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arthritis care & research     Volume:  62     ISSN:  2151-4658     ISO Abbreviation:  Arthritis Care Res (Hoboken)     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-12     Completed Date:  2010-06-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101518086     Medline TA:  Arthritis Care Res (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  712-8     Citation Subset:  IM    
University of Perugia, Perugia, Italy.
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MeSH Terms
Atherosclerosis / blood,  complications*,  pathology
Brachial Artery / pathology,  physiopathology*
Case-Control Studies
Endothelium, Vascular / metabolism,  pathology,  physiopathology*
Intercellular Adhesion Molecule-1 / blood
Matched-Pair Analysis
Middle Aged
Reference Values
Sjogren's Syndrome / blood,  complications,  pathology*
Statistics, Nonparametric
Tyrosine / analogs & derivatives,  metabolism
Vascular Cell Adhesion Molecule-1 / blood
Vasodilation / physiology*
Reg. No./Substance:
0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1; 3604-79-3/3-nitrotyrosine; 55520-40-6/Tyrosine

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