| Functional imaging: what evidence is there for its utility in clinical trials of targeted therapies? | |
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MedLine Citation:
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PMID: 22281664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Key issues in early clinical trials of targeted agents include the determination of target inhibition, rational patient selection based on pre-treatment tumour characteristics, and assessment of tumour response in the absence of actual shrinkage. There is accumulating evidence that functional imaging using advanced techniques such as dynamic contrast enhanced (DCE)-magnetic resonance imaging (MRI), DCE-computerised tomography (CT) and DCE-ultrasound, diffusion weighted-MRI, magnetic resonance spectroscopy and positron emission tomography-CT using various labelled radioactive tracers has the potential to address all three. This article reviews this evidence with examples from trials using targeted agents with established clinical efficacy and summarises the clinical utility of the various techniques. We therefore recommend that input from specialist radiologists is sought at the early stages of trial design, in order to ensure that functional imaging is incorporated appropriately for the agent under study. There is an urgent need to strengthen the evidence base for these techniques as they evolve, and to ensure standardisation of the methodology. |
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Authors:
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N Tunariu; S B Kaye; N M Desouza |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2012-01-26 |
Journal Detail:
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Title: British journal of cancer Volume: 106 ISSN: 1532-1827 ISO Abbreviation: Br. J. Cancer Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-15 Completed Date: 2012-03-29 Revised Date: 2012-04-11 |
Medline Journal Info:
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Nlm Unique ID: 0370635 Medline TA: Br J Cancer Country: England |
Other Details:
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Languages: eng Pagination: 619-28 Citation Subset: IM |
Affiliation:
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Section of Clinical Magnetic Resonance, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey SM2 5PT, UK. nina.tunariu@icr.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Clinical Trials as Topic* Diagnostic Imaging / methods* Drug Administration Schedule Humans Magnetic Resonance Imaging / methods Molecular Targeted Therapy* Neoplasms / therapy* Positron-Emission Tomography and Computed Tomography Tomography, X-Ray Computed |
| Grant Support | |
ID/Acronym/Agency:
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C1060/A10334//Department of Health; //Cancer Research UK; //Medical Research Council |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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