Document Detail

Functional imaging of neural responses to expectancy and experience of monetary gains and losses.
MedLine Citation:
PMID:  11395019     Owner:  NLM     Status:  MEDLINE    
Neural responses accompanying anticipation and experience of monetary gains and losses were monitored by functional magnetic resonance imaging. Trials comprised an initial "prospect" (expectancy) phase, when a set of three monetary amounts was displayed, and a subsequent "outcome" phase, when one of these amounts was awarded. Hemodynamic responses in the sublenticular extended amygdala (SLEA) and orbital gyrus tracked the expected values of the prospects, and responses to the highest value set of outcomes increased monotonically with monetary value in the nucleus accumbens, SLEA, and hypothalamus. Responses to prospects and outcomes were generally, but not always, seen in the same regions. The overlap of the observed activations with those seen previously in response to tactile stimuli, gustatory stimuli, and euphoria-inducing drugs is consistent with a contribution of common circuitry to the processing of diverse rewards.
H C Breiter; I Aharon; D Kahneman; A Dale; P Shizgal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuron     Volume:  30     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-06-07     Completed Date:  2001-06-28     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  619-39     Citation Subset:  IM    
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MeSH Terms
Amygdala / blood supply,  physiology
Analysis of Variance
Brain / physiology*
Brain Mapping*
Brain Stem / physiology
Cerebral Cortex / physiology
Cerebrovascular Circulation
Hypothalamus / physiology
Magnetic Resonance Imaging
Nucleus Accumbens / physiology
Play and Playthings*
Visual Pathways / physiology
Grant Support
00265//PHS HHS; 09467//PHS HHS; P41-RR14075/RR/NCRR NIH HHS; R01-NS39581/NS/NINDS NIH HHS; R01-RR13609/RR/NCRR NIH HHS

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