Document Detail

Functional imaging of memory processes in humans: positron emission tomography and functional magnetic resonance imaging.
MedLine Citation:
PMID:  18374275     Owner:  NLM     Status:  MEDLINE    
Human memory is not a unitary function; it consists of multiple memory systems, with different characteristics and specialisations that are implemented in the brain. The cognitive neuroscience of human memory tries to comprehend how we encode, store, and retrieve memory items within and across those systems. The emergence of functional neuroimaging techniques offered the unprecedented opportunity to directly observe the brain regions engaged in memory functions. Brain imaging techniques can roughly be divided into those measuring the electric or magnetic fields generated by neuronal activity (EEG, magnetencephalography [MEG]) and those measuring the haemodynamic or metabolic sequelae of neuronal activity (positron emission tomography [PET], functional magnetic resonance imaging [fMRI]). Out of these techniques, the following two will be discussed in detail: fMRI and PET. Although functional neuroimaging is able to acquire images of the brain engaged in consolidating or retrieving memories, these processes are not clearly visible in the data. Statistical techniques are needed to reduce the complexity of the data and to extract the processes of interest. This article outlines the experimental and analytical procedures of neuroimaging studies with PET and fMRI. We will use a PET-study on episodic memory in human volunteers to illustrate design, analysis, and interpretation of functional imaging studies on memory.
T D Poeppel; B J Krause
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Methods (San Diego, Calif.)     Volume:  44     ISSN:  1046-2023     ISO Abbreviation:  Methods     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-31     Completed Date:  2008-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9426302     Medline TA:  Methods     Country:  United States    
Other Details:
Languages:  eng     Pagination:  315-28     Citation Subset:  IM    
Department of Nuclear Medicine (KME) of the Heinrich Heine University Duesseldorf, Research Centre Juelich, Juelich, Germany.
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MeSH Terms
Magnetic Resonance Imaging / methods*
Memory* / classification,  physiology
Memory Disorders / diagnosis*,  radionuclide imaging
Positron-Emission Tomography / methods*

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