| Functional human Th17 clones with WT1-specific helper activity. | |
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MedLine Citation:
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PMID: 23275045 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Th17 plays important roles in the pathogenesis of various inflammatory and autoimmune diseases. Although the importance of Th17 in tumor immunity has also been suggested, precise roles of tumor-associated antigen-specific Th17 still remain poorly understood, especially in humans. We previously identified WT1(332), a 16-mer helper epitope derived from tumor-associated antigen Wilms' tumor gene 1 (WT1) product, and WT1(332)-specific Th1 clones were established. In the present study, WT1-specific Th17 clones were established by the stimulation of peripheral blood mononuclear cells with the WT1(332) helper peptide under human Th17-polarizing conditions. The WT1-specific Th17 clone exhibited the helper function for proliferation of conventional CD4(+) T cells in the antigenic stimulation-specific manner. This is the first report of establishment of functional Th17 clones with both antigen (WT1(332)) specificity and antigen-specific helper activity. Th17 clones established here and the method to establish antigen-specific Th17 clones should be a useful tool to further analyze the roles of human Th17 in tumor immunity. |
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Authors:
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Sho Tachino; Fumihiro Fujiki; Yoshihiro Oka; Akihiro Tsuboi; Soyoko Morimoto; Yu-Hung Lin; Taichi Tamanaka; Kenta Kondo; Hiroko Nakajima; Sumiyuki Nishida; Naoki Hosen; Yusuke Oji; Atsushi Kumanogoh; Haruo Sugiyama |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-29 |
Journal Detail:
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Title: Cancer immunology, immunotherapy : CII Volume: - ISSN: 1432-0851 ISO Abbreviation: Cancer Immunol. Immunother. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8605732 Medline TA: Cancer Immunol Immunother Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, Japan, stachino@imed3.med.osaka-u.ac.jp. |
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