Document Detail


Functional genomics and proteomics: charting a multidimensional map of the yeast cell.
MedLine Citation:
PMID:  12837605     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The challenge of large-scale functional genomics projects is to build a comprehensive map of the cell including genome sequence and gene expression data, information on protein localization, structure, function and expression, post-translational modifications, molecular and genetic interactions and phenotypic descriptions. Some of this broad set of functional genomics data has been already assembled for the budding yeast. Even though molecular cartography of the yeast cell is still far from comprehensive, functional genomics has begun to forge connections between disparate cellular events and to foster numerous hypotheses. Here we review several different genomics and proteomics technologies and describe bioinformatics methods for exploring these data to make new discoveries.
Authors:
Gary D Bader; Adrian Heilbut; Brenda Andrews; Mike Tyers; Timothy Hughes; Charles Boone
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Trends in cell biology     Volume:  13     ISSN:  0962-8924     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-02     Completed Date:  2003-09-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  344-56     Citation Subset:  IM    
Affiliation:
Computational Biology Center, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 460, 10021, New York, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Chromosome Mapping*
Computational Biology
Gene Expression Regulation, Fungal / genetics*
Genomics*
Nuclear Proteins / genetics,  metabolism
Proteomics*
Saccharomyces cerevisiae / genetics*,  metabolism*,  ultrastructure
Saccharomyces cerevisiae Proteins / genetics*,  metabolism*
Signal Transduction / genetics
Chemical
Reg. No./Substance:
0/Nuclear Proteins; 0/Saccharomyces cerevisiae Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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