| Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans. | |
| | |
MedLine Citation:
|
PMID: 23299892 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. Here by integrating transcriptional analysis and functional genomics, we identified Candida-specific host defence mechanisms in humans. Candida induced significant expression of genes from the type I interferon pathway in human peripheral blood mononuclear cells. This unexpectedly prominent role of type I interferon pathway in anti-Candida host defence was supported by additional evidence. Polymorphisms in type I interferon genes modulated Candida-induced cytokine production and were correlated with susceptibility to systemic candidiasis. In in vitro experiments, type I interferons skewed Candida-induced inflammation from a Th17 response towards a Th1 response. Patients with chronic mucocutaneous candidiasis displayed defective expression of genes in the type I interferon pathway. These findings indicate that the type I interferon pathway is a main signature of Candida-induced inflammation and has a crucial role in anti-Candida host defence in humans. |
| | |
Authors:
|
Sanne P Smeekens; Aylwin Ng; Vinod Kumar; Melissa D Johnson; Theo S Plantinga; Cleo van Diemen; Peer Arts; Eugène T P Verwiel; Mark S Gresnigt; Karin Fransen; Suzanne van Sommeren; Marije Oosting; Shih-Chin Cheng; Leo A B Joosten; Alexander Hoischen; Bart-Jan Kullberg; William K Scott; John R Perfect; Jos W M van der Meer; Cisca Wijmenga; Mihai G Netea; Ramnik J Xavier |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Nature communications Volume: 4 ISSN: 2041-1723 ISO Abbreviation: Nat Commun Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-01-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101528555 Medline TA: Nat Commun Country: England |
Other Details:
|
Languages: eng Pagination: 1342 Citation Subset: IM |
Affiliation:
|
1] Department of Medicine (463), Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 8, 6525GA Nijmegen, The Netherlands [2] Nijmegen Institute for Infection, Inflammation, and Immunity (N4i) (463), PO Box 9101, 6500 HB Nijmegen, The Netherlands [3]. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Kinship reduces alloparental care in cooperative cichlids where helpers pay-to-stay.
Next Document: The bipolar assembly domain of the mitotic motor kinesin-5.