Document Detail

Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging.
MedLine Citation:
PMID:  15547316     Owner:  NLM     Status:  MEDLINE    
Aging is associated with mitochondrial dysfunctions, which trigger membrane leakage, release of reactive species from oxygen and nitrogen and subsequent induction of peroxidative reactions that result in biomolecules' damaging and releasing of metals with amplification of free radicals discharge. Free radicals induce neuronal cell death increasing tissue loss, which could be associated with memory detriment. These pathological events are involved in cardiovascular, neurodegenerative and carcinogenic processes. Dietary bioactive compounds from different functional foods, herbs and nutraceuticals (ginseng, ginkgo, nuts, grains, tomato, soy phytoestrogens, curcumin, melatonin, polyphenols, antioxidant vitamins, carnitine, carnosine, ubiquinone, etc.) can ameliorate or even prevent diseases. Protection from chronic diseases of aging involves antioxidant activities, mitochondrial stabilizing functions, metal chelating activities, inhibition of apoptosis of vital cells, and induction of cancer cell apoptosis. Functional foods and nutraceuticals constitute a great promise to improve health and prevent aging-related chronic diseases.
Carlos K B Ferrari
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biogerontology     Volume:  5     ISSN:  1389-5729     ISO Abbreviation:  Biogerontology     Publication Date:  2004  
Date Detail:
Created Date:  2004-11-19     Completed Date:  2005-04-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100930043     Medline TA:  Biogerontology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  275-89     Citation Subset:  IM    
Department of Nutrition, Faculty of Public Health, University of São Paulo, Av Dr. Arnaldo, 715, 2 andar, 01246-904, São Paulo (SP), Brazil.
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MeSH Terms
Aging / physiology*
Antioxidants / pharmacology
Chelating Agents / pharmacology
Heart Diseases / prevention & control
Herbal Medicine*
Homocysteine / metabolism
Lipoproteins, LDL / metabolism
Mitochondrial Diseases / physiopathology
Oxidative Stress
Reg. No./Substance:
0/Antioxidants; 0/Chelating Agents; 0/Lipoproteins, LDL; 454-28-4/Homocysteine

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