| Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies. | |
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MedLine Citation:
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PMID: 20508825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obesity is associated with a low-grade systemic chronic inflammatory state, characterized by the abnormal production of pro- and anti-inflammatory adipocytokines. It has been found that immune cells such as macrophages can infiltrate adipose tissue and are responsible for the majority of inflammatory cytokine production. Obesity-induced inflammation is considered a potential mechanism linking obesity to its related pathologies, such as insulin resistance, cardiovascular diseases, type-2 diabetes, and some immune disorders. Therefore, targeting obesity-related inflammatory components may be a useful strategy to prevent or ameliorate the development of such obesity-related diseases. It has been shown that several food components can modulate inflammatory responses in adipose tissue via various mechanisms, some of which are dependent on peroxisome proliferator-activated receptor gamma (PPARgamma), whereas others are independent on PPARgamma, by attenuating signals of nuclear factor-kappaB (NF-kappaB) and/or c-Jun amino-terminal kinase (JNK). In this review, we introduce the beneficial effects of anti-inflammatory phytochemicals that can help prevent obesity-induced inflammatory responses and pathologies. |
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Authors:
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Shizuka Hirai; Nobuyuki Takahashi; Tsuyoshi Goto; Shan Lin; Taku Uemura; Rina Yu; Teruo Kawada |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-05-25 |
Journal Detail:
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Title: Mediators of inflammation Volume: 2010 ISSN: 1466-1861 ISO Abbreviation: Mediators Inflamm. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-05-28 Completed Date: 2010-09-27 Revised Date: 2010-09-30 |
Medline Journal Info:
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Nlm Unique ID: 9209001 Medline TA: Mediators Inflamm Country: United States |
Other Details:
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Languages: eng Pagination: 367838 Citation Subset: IM |
Affiliation:
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Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipokines
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immunology Adipose Tissue / immunology Animals Functional Food* Humans Inflammation* / diet therapy, etiology, immunology Insulin Resistance Obesity* / complications, immunology, pathology PPAR gamma / metabolism Plant Extracts / metabolism Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Adipokines; 0/PPAR gamma; 0/Plant Extracts |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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