| Functional feedback from mushroom bodies to antennal lobes in the Drosophila olfactory pathway. | |
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MedLine Citation:
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PMID: 20479249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Feedback plays important roles in sensory processing. Mushroom bodies are believed to be involved in olfactory learning/memory and multisensory integration in insects. Previous cobalt-labeling studies have suggested the existence of feedback from the mushroom bodies to the antennal lobes in the honey bee. In this study, the existence of functional feedback from Drosophila mushroom bodies to the antennal lobes was investigated through ectopic expression of the ATP receptor P2X(2) in the Kenyon cells of mushroom bodies. Activation of Kenyon cells induced depolarization in projection neurons and local interneurons in the antennal lobes in a nicotinic receptor-dependent manner. Activation of Kenyon cell axons in the betagamma-lobes in the mushroom body induced more potent responses in the antennal lobe neurons than activation of Kenyon cell somata. Our results indicate that functional feedback from Kenyon cells to projection neurons and local interneurons is present in Drosophila and is likely mediated by the betagamma-lobes. The presence of this functional feedback from the mushroom bodies to the antennal lobes suggests top-down modulation of olfactory information processing in Drosophila. |
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Authors:
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Aiqun Hu; Wei Zhang; Zuoren Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-17 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-06-29 Revised Date: 2011-03-03 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 10262-7 Citation Subset: IM |
Affiliation:
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Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, and Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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physiology Adenosine Triphosphate / pharmacology Animals Animals, Genetically Modified Drosophila / drug effects, genetics, physiology* Electrophysiological Phenomena Feedback, Sensory Interneurons / physiology Mushroom Bodies / drug effects, physiology* Olfactory Pathways / drug effects, physiology* Olfactory Receptor Neurons / physiology Patch-Clamp Techniques Receptors, Purinergic P2 / genetics, metabolism Receptors, Purinergic P2X2 Recombinant Proteins / genetics, metabolism Sensory Receptor Cells / physiology Synaptic Transmission |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Purinergic P2; 0/Receptors, Purinergic P2X2; 0/Recombinant Proteins; 51-84-3/Acetylcholine; 56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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