Document Detail


Functional expression of ERG1 potassium channels in rat alveolar macrophages.
MedLine Citation:
PMID:  23138560     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Alveolar macrophages (AMs) play a vital role in lung immunity. The recent studies demonstrated that potassium channels were associated with macrophage functions, such as activation, migration and cytokines secretion. However, less is known regarding the expression and function of ERG channels in AMs. Our study showed that ERG1 channel expressed in rat alveolar macrophage, and the expression level was increased when AMs were stimulated with LPS. Furthermore, blockade of ERG1 channels with E4031 down-regulated the mature of ERG1 protein, inhibited NF-κB translocation into the nucleus, and reduced LPS-stimulated IL-6 and IL-1β secretion. These results imply that ERG1 channels are functionally expressed in rat alveolar macrophages and play an important role in inflammatory response.
Authors:
Haiying Dong; Zhenyu Ji; Manling Liu; Yanxia Wang; Xiao Bai; Ting Wang; Zidong Liu; Yousheng Wu; Bo Zhang; Ying Luo; Zhichao Li; Mingqing Dong
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  Journal of molecular histology     Volume:  -     ISSN:  1567-2387     ISO Abbreviation:  J. Mol. Histol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101193653     Medline TA:  J Mol Histol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pathology and Pathophysiology, Fourth Military Medical University, Changle West Road 169, Xi'an, 710032, People's Republic of China.
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