| Functional drug-gene interactions in lung cancer. | |
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MedLine Citation:
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PMID: 22468819 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Despite the dawn of the genomic information era, the challenges of cancer treatment remain formidable. Particularly for the most prevalent cancer types, including lung cancer, successful treatment of metastatic disease is rare and escalating costs for modern targeted drugs place an increasing strain on healthcare systems. Although powerful diagnostic tools to characterize individual tumor samples in great molecular detail are becoming rapidly available, the transformation of this information into therapy provides a major challenge. A fundamental difficulty is the molecular complexity of cancer cells that often causes drug resistance, but can also render tumors exquisitely sensitive to targeted agents. By using lung cancer as an example, we outline the principles that govern drug sensitivity and resistance from a genetic perspective and discuss how in vitro chemical-genetic screens can impact on patient stratification in the clinic. |
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Authors:
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Michal Smida; Sebastian Mb Nijman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of molecular diagnostics Volume: 12 ISSN: 1744-8352 ISO Abbreviation: Expert Rev. Mol. Diagn. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101120777 Medline TA: Expert Rev Mol Diagn Country: England |
Other Details:
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Languages: eng Pagination: 291-302 Citation Subset: IM |
Affiliation:
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CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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