Document Detail

Functional diversity of actin cytoskeleton in neurons and its regulation by tropomyosin.
MedLine Citation:
PMID:  22878104     Owner:  NLM     Status:  In-Data-Review    
Neurons comprise functionally, molecularly, and spatially distinct subcellular compartments which include the soma, dendrites, axon, branches, dendritic spines, and growth cones. In this chapter, we detail the remarkable ability of the neuronal cytoskeleton to exquisitely regulate all these cytoplasmic distinct partitions, with particular emphasis on the microfilament system and its plethora of associated proteins. Importance will be given to the family of actin-associated proteins, tropomyosin, in defining distinct actin filament populations. The ability of tropomyosin isoforms to regulate the access of actin-binding proteins to the filaments is believed to define the structural diversity and dynamics of actin filaments and ultimately be responsible for the functional outcome of these filaments.
Galina Schevzov; Nikki Margarita Curthoys; Peter William Gunning; Thomas Fath
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International review of cell and molecular biology     Volume:  298     ISSN:  1937-6448     ISO Abbreviation:  Int Rev Cell Mol Biol     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101475846     Medline TA:  Int Rev Cell Mol Biol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  33-94     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Oncology Research Unit, Department of Pharmacology, School of Medical Sciences, University of New South Wales, Kensington, New South Wales, Australia.
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