| Functional disorder of the retina in manganese-deficient Japanese quail revealed by electroretinography using a contact lens electrode with built-in light source. | |
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MedLine Citation:
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PMID: 18319573 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Manganese deficiency results in neurological and skeletal defects, together with ultrastructural disarrangement of the retina in rats. Wild birds show a range of Mn concentrations in their tissues, including the liver, raising the possibility of Mn-related disorders in the wild. Electroretinography (ERG) provides a useful noninvasive approach to evaluate visual function. This method is especially useful in birds, as objective analysis of them is very difficult, while they have well-developed vision. In this study, we carried out a convenient and reliable ERG recording using a contact lens electrode with a built-in light source (LED electrode) of Japanese quail (Coturnix coturnix japonica) fed a Mn-deficient diet. After 10 min light adaptation, single-flash and flicker cone responses were reproducibly recorded to cause an intensity-dependent increase in amplitude of both a-wave and b-wave in single-flash ERG. Mn-deficient feeding markedly decreased the Mn concentration in the liver by almost half in 3 to 6 weeks, followed by body weight loss in 13 to 15 weeks. Implicit time of a-wave and b-wave cone response by single-flash stimulation was significantly delayed in quail with a Mn depletion from 3 to 6 weeks. Every cone response of the Mn-deprived quail had a tendency to decrease amplitude. The ultrastructure of cone photoreceptor cells was disorganized by Mn deficiency, including changes in outer segment discs of photoreceptor cells. These results suggest the essential role of Mn in the integrity of the retinal function of birds. |
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Authors:
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Kentaro Endo; Norihiko Itoh; Seiya Maehara; Aya Shinozaki; Tomohiro Imagawa; Masato Uehara; Naoharu Mizuno; Shoji Sasaki; Takeo Hiraga; Hiroki Teraoka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of veterinary medical science / the Japanese Society of Veterinary Science Volume: 70 ISSN: 0916-7250 ISO Abbreviation: J. Vet. Med. Sci. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-03-05 Completed Date: 2008-04-11 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9105360 Medline TA: J Vet Med Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 139-44 Citation Subset: IM |
Affiliation:
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Department of Toxicology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed Animal Nutritional Physiological Phenomena Animals Contact Lenses / veterinary Coturnix* Diet / veterinary Electrodes / veterinary Electroretinography / instrumentation, veterinary* Manganese / deficiency* Poultry Diseases / pathology* Retina / ultrastructure Retinal Diseases / pathology, veterinary* |
| Chemical | |
Reg. No./Substance:
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7439-96-5/Manganese |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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