| Functional disability 5 years after acute respiratory distress syndrome. | |
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MedLine Citation:
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PMID: 21470008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There have been few detailed, in-person interviews and examinations to obtain follow-up data on 5-year outcomes among survivors of the acute respiratory distress syndrome (ARDS). METHODS: We evaluated 109 survivors of ARDS at 3, 6, and 12 months and at 2, 3, 4, and 5 years after discharge from the intensive care unit. At each visit, patients were interviewed and examined; underwent pulmonary-function tests, the 6-minute walk test, resting and exercise oximetry, chest imaging, and a quality-of-life evaluation; and reported their use of health care services. RESULTS: At 5 years, the median 6-minute walk distance was 436 m (76% of predicted distance) and the Physical Component Score on the Medical Outcomes Study 36-Item Short-Form Health Survey was 41 (mean norm score matched for age and sex, 50). With respect to this score, younger patients had a greater rate of recovery than older patients, but neither group returned to normal predicted levels of physical function at 5 years. Pulmonary function was normal to near-normal. A constellation of other physical and psychological problems developed or persisted in patients and family caregivers for up to 5 years. Patients with more coexisting illnesses incurred greater 5-year costs. CONCLUSIONS: Exercise limitation, physical and psychological sequelae, decreased physical quality of life, and increased costs and use of health care services are important legacies of severe lung injury. |
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Authors:
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Margaret S Herridge; Catherine M Tansey; Andrea Matté; George Tomlinson; Natalia Diaz-Granados; Andrew Cooper; Cameron B Guest; C David Mazer; Sangeeta Mehta; Thomas E Stewart; Paul Kudlow; Deborah Cook; Arthur S Slutsky; Angela M Cheung; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The New England journal of medicine Volume: 364 ISSN: 1533-4406 ISO Abbreviation: N. Engl. J. Med. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-07 Completed Date: 2011-04-11 Revised Date: 2011-07-21 |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: United States |
Other Details:
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Languages: eng Pagination: 1293-304 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University Health Network, University of Toronto, Toronto, ON, Canada. margaret.herridge@uhn.on.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living Adult Disabled Persons* Exercise Test Female Follow-Up Studies Health Services / utilization Humans Kaplan-Meier Estimate Lung / physiology Male Middle Aged Quality of Life* Recovery of Function Respiratory Distress Syndrome, Adult / complications*, physiopathology, psychology Respiratory Function Tests Survivors / psychology Walking Work |
| Comments/Corrections | |
Comment In:
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N Engl J Med. 2011 Jul 21;365(3):275; author reply 275-6
[PMID:
21774724
]
N Engl J Med. 2011 Apr 7;364(14):1358-9 [PMID: 21470014 ] N Engl J Med. 2011 Jul 21;365(3):274-5; author reply 275-6 [PMID: 21774725 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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