Document Detail

Functional disability 5 years after acute respiratory distress syndrome.
MedLine Citation:
PMID:  21470008     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There have been few detailed, in-person interviews and examinations to obtain follow-up data on 5-year outcomes among survivors of the acute respiratory distress syndrome (ARDS).
METHODS: We evaluated 109 survivors of ARDS at 3, 6, and 12 months and at 2, 3, 4, and 5 years after discharge from the intensive care unit. At each visit, patients were interviewed and examined; underwent pulmonary-function tests, the 6-minute walk test, resting and exercise oximetry, chest imaging, and a quality-of-life evaluation; and reported their use of health care services.
RESULTS: At 5 years, the median 6-minute walk distance was 436 m (76% of predicted distance) and the Physical Component Score on the Medical Outcomes Study 36-Item Short-Form Health Survey was 41 (mean norm score matched for age and sex, 50). With respect to this score, younger patients had a greater rate of recovery than older patients, but neither group returned to normal predicted levels of physical function at 5 years. Pulmonary function was normal to near-normal. A constellation of other physical and psychological problems developed or persisted in patients and family caregivers for up to 5 years. Patients with more coexisting illnesses incurred greater 5-year costs.
CONCLUSIONS: Exercise limitation, physical and psychological sequelae, decreased physical quality of life, and increased costs and use of health care services are important legacies of severe lung injury.
Margaret S Herridge; Catherine M Tansey; Andrea Matté; George Tomlinson; Natalia Diaz-Granados; Andrew Cooper; Cameron B Guest; C David Mazer; Sangeeta Mehta; Thomas E Stewart; Paul Kudlow; Deborah Cook; Arthur S Slutsky; Angela M Cheung;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The New England journal of medicine     Volume:  364     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-07     Completed Date:  2011-04-11     Revised Date:  2011-07-21    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1293-304     Citation Subset:  AIM; IM    
Department of Medicine, University Health Network, University of Toronto, Toronto, ON, Canada.
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MeSH Terms
Activities of Daily Living
Disabled Persons*
Exercise Test
Follow-Up Studies
Health Services / utilization
Kaplan-Meier Estimate
Lung / physiology
Middle Aged
Quality of Life*
Recovery of Function
Respiratory Distress Syndrome, Adult / complications*,  physiopathology,  psychology
Respiratory Function Tests
Survivors / psychology
Comment In:
N Engl J Med. 2011 Jul 21;365(3):275; author reply 275-6   [PMID:  21774724 ]
N Engl J Med. 2011 Apr 7;364(14):1358-9   [PMID:  21470014 ]
N Engl J Med. 2011 Jul 21;365(3):274-5; author reply 275-6   [PMID:  21774725 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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