Document Detail

Functional development of the visual system in human fetus using magnetoencephalography.
MedLine Citation:
PMID:  15498542     Owner:  NLM     Status:  MEDLINE    
The development of the human brain in utero is normally regarded as a dynamic process involving mainly structural and quantitative changes in neurons and their distribution. However, it is generally accepted that a parallel development of functional specialization occurs in certain areas of the brain, especially in the primary cortex. Nearly all knowledge of functional fetal brain development has been obtained from various animal studies rather than human studies. These studies show that the primary sensory areas like auditory, visual, and somatosensory cortex show a basic function similar to that of a fully developed brain. It has been specifically shown that the visual system develops during fetal life and becomes functional before birth. Several studies have demonstrated the feasibility of using visual evoked response (VER) recordings on preterm human infants to follow the functional development of the visual system. With the advent of the noninvasive technique of magnetoencephalography (MEG), human fetal VER recordings are now possible thus providing the opportunity to track its functional development with gestation. We present and discuss the results of VER recordings in human fetuses starting at 28 weeks of gestation performed using a 151-channel MEG system.
Hari Eswaran; Curtis L Lowery; James D Wilson; Pam Murphy; Hubert Preissl
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental neurology     Volume:  190 Suppl 1     ISSN:  0014-4886     ISO Abbreviation:  Exp. Neurol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-22     Completed Date:  2005-02-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S52-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
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MeSH Terms
Evoked Potentials, Visual / physiology*
Feasibility Studies
Fetal Development / physiology
Fetus / physiology*
Gestational Age
Magnetoencephalography / methods*
Photic Stimulation / instrumentation,  methods
Reaction Time / physiology
Ultrasonography, Prenatal
Visual Pathways / embryology,  physiology*
Grant Support

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