| Functional deficits and morphological changes in the neurogenic bladder match the severity of spinal cord compression. | |
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MedLine Citation:
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PMID: 22695706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE AND METHODS: We used a clinically relevant model of thoracic SCI compression injury in adult female Wistar rats and confirmed that lesion volumes following severe injuries were significantly greater compared to moderate injuries (p < 0.05). Between 1-9 weeks, we assessed recovery of bladder function as well as return of locomotor function using the Basso, Beattie and Bresnahan (BBB) score. Bladder morphometrics and overall intramural innervation patterns, as assessed with ß-III tubulin immunohistochemistry, were also examined. RESULTS: Despite variability, bladder function was significantly worse following severe compared to moderate compression injury (p < 0.05); furthermore, the degree of bladder and locomotor dysfunction were significantly correlated (r = 0.59; p < 0.05). In addition, at 9 weeks after SCI we saw significantly greater increases in bladder dry weight (p < 0.05) and wall thickness following severe compared to moderate injury as well as increases in intramural axon density (moderate: 3× normal values; severe 5×; both p < 0.05) that also correlated with injury severity (r = 0.89). CONCLUSION: The moderate and severe compression models show consistent and correlated deficits in bladder and locomotor function, as well as in gross anatomical and histopathological changes. Increased intramural innervation may contribute to neurogenic detrusor overactivity and suggests the use of therapeutic agents which block visceromotoric efferents. |
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Authors:
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O Ozsoy; U Ozsoy; G Stein; O Semler; E Skouras; G Schempf; K Wellmann; F Wirth; S Angelova; J Ankerne; M Ashrafi; E Schönau; T Papamitsou-Sidoropolou; P Jaminet; L Sarikcioglu; A Irintchev; S A Dunlop; D N Angelov |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Restorative neurology and neuroscience Volume: 30 ISSN: 1878-3627 ISO Abbreviation: Restor. Neurol. Neurosci. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-09-07 Completed Date: 2013-02-06 Revised Date: 2013-04-10 |
Medline Journal Info:
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Nlm Unique ID: 9005499 Medline TA: Restor Neurol Neurosci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 363-81 Citation Subset: IM |
Affiliation:
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Department of Physiology, Akdeniz University, Antalya, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Female Locomotion / physiology Motor Activity / physiology Movement Disorders / etiology* Nerve Fibers, Myelinated / pathology Organ Size / physiology Peripheral Nerves / pathology Rats Rats, Wistar Recovery of Function / physiology* Regression Analysis Severity of Illness Index Spinal Cord Compression / complications*, pathology* Time Factors Tubulin / metabolism Urinary Bladder / pathology, physiopathology Urinary Bladder, Neurogenic / etiology*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Tubulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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