Document Detail

Functional deficits and morphological changes in the neurogenic bladder match the severity of spinal cord compression.
MedLine Citation:
PMID:  22695706     Owner:  NLM     Status:  MEDLINE    
PURPOSE AND METHODS: We used a clinically relevant model of thoracic SCI compression injury in adult female Wistar rats and confirmed that lesion volumes following severe injuries were significantly greater compared to moderate injuries (p < 0.05). Between 1-9 weeks, we assessed recovery of bladder function as well as return of locomotor function using the Basso, Beattie and Bresnahan (BBB) score. Bladder morphometrics and overall intramural innervation patterns, as assessed with ß-III tubulin immunohistochemistry, were also examined.
RESULTS: Despite variability, bladder function was significantly worse following severe compared to moderate compression injury (p < 0.05); furthermore, the degree of bladder and locomotor dysfunction were significantly correlated (r = 0.59; p < 0.05). In addition, at 9 weeks after SCI we saw significantly greater increases in bladder dry weight (p < 0.05) and wall thickness following severe compared to moderate injury as well as increases in intramural axon density (moderate: 3× normal values; severe 5×; both p < 0.05) that also correlated with injury severity (r = 0.89).
CONCLUSION: The moderate and severe compression models show consistent and correlated deficits in bladder and locomotor function, as well as in gross anatomical and histopathological changes. Increased intramural innervation may contribute to neurogenic detrusor overactivity and suggests the use of therapeutic agents which block visceromotoric efferents.
O Ozsoy; U Ozsoy; G Stein; O Semler; E Skouras; G Schempf; K Wellmann; F Wirth; S Angelova; J Ankerne; M Ashrafi; E Schönau; T Papamitsou-Sidoropolou; P Jaminet; L Sarikcioglu; A Irintchev; S A Dunlop; D N Angelov
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Restorative neurology and neuroscience     Volume:  30     ISSN:  1878-3627     ISO Abbreviation:  Restor. Neurol. Neurosci.     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-07     Completed Date:  2013-02-06     Revised Date:  2013-04-10    
Medline Journal Info:
Nlm Unique ID:  9005499     Medline TA:  Restor Neurol Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  363-81     Citation Subset:  IM    
Department of Physiology, Akdeniz University, Antalya, Turkey.
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MeSH Terms
Disease Models, Animal
Locomotion / physiology
Motor Activity / physiology
Movement Disorders / etiology*
Nerve Fibers, Myelinated / pathology
Organ Size / physiology
Peripheral Nerves / pathology
Rats, Wistar
Recovery of Function / physiology*
Regression Analysis
Severity of Illness Index
Spinal Cord Compression / complications*,  pathology*
Time Factors
Tubulin / metabolism
Urinary Bladder / pathology,  physiopathology
Urinary Bladder, Neurogenic / etiology*,  pathology
Reg. No./Substance:

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