| Functional decoupling of BOLD and gamma-band amplitudes in human primary visual cortex. | |
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MedLine Citation:
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PMID: 18729078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although functional magnetic resonance imaging is an important tool for measuring brain activity, the hemodynamic blood oxygenation level dependent (BOLD) response is only an indirect measure of neuronal activity. Converging evidence obtained from simultaneous recording of hemodynamic and electrical measures suggest that the best correlate of the BOLD response in primary visual cortex is gamma-band oscillations ( approximately 40 Hz). Here, we examined the coupling between BOLD and gamma-band amplitudes measured with magntoencephalography (MEG) in human primary visual cortex in 10 participants. In Experiment A, participants were exposed to grating stimuli at two contrast levels and two spatial frequencies and in Experiment B square and sine wave stimuli at two spatial frequencies. The amplitudes of both gamma-band oscillations and BOLD showed tuning with stimulus contrast and stimulus type; however, gamma-band oscillations showed a 300% increase across two spatial frequencies, whereas BOLD exhibited no change. This functional decoupling demonstrates that increased amplitude of gamma-band oscillations as measured with MEG is not sufficient to drive the subsequent BOLD response. |
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Authors:
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Suresh D Muthukumaraswamy; Krish D Singh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Human brain mapping Volume: 30 ISSN: 1097-0193 ISO Abbreviation: Hum Brain Mapp Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-22 Completed Date: 2009-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9419065 Medline TA: Hum Brain Mapp Country: United States |
Other Details:
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Languages: eng Pagination: 2000-7 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Wiley-Liss, Inc |
Affiliation:
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Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff CF10 3AT, United Kingdom. sdmuthu@cardiff.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Brain Mapping Female Humans Magnetic Resonance Imaging Magnetoencephalography Male Oxygen / blood* Periodicity* Visual Cortex / physiology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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BBS/B/08035//Biotechnology and Biological Sciences Research Council |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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