| Functional correlates of lung involvement in Wegener's granulomatosis. Use of pulmonary function tests in staging and follow-up. | |
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MedLine Citation:
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PMID: 7416186 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To examine the usefulness of pulmonary function testing in the clinical management of patients with Wegener's granulomatosis, 22 subjects with biopsy proved disease were evaluated using routine functional parameters. Although reduced lung volumes and diffusing capacity occurred frequently, the most common abnormality was in obstruction to airflow. Comparison of these functional parameters with roentgenographic and clinical findings revealed that reduced lung volumes were useful in detecting focal infiltrates, mass or cavitary lesions and diffuse interstitial involvement whereas airflow measurements were useful in detecting focal large airway lesions. In people with evidence of limitation of airflow, respiratory complications frequently developed in the form of acute tracheal obstruction of lobar collapse. In addition, serial evaluation of lung function during treatment revealed that although in most patients lung volumes and airflow obstruction improved or stabilized, a reduction of diffusing capacity was common. These studies suggest that routine pulmonary function testing may be a useful tool in the staging of patients with Wegener's granulomatosis and in following responses to therapy. |
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Authors:
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D M Rosenberg; S E Weinberger; J D Fulmer; M W Flye; A S Fauci; R G Crystal |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of medicine Volume: 69 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1980 Sep |
Date Detail:
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Created Date: 1980-11-24 Completed Date: 1980-11-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 387-94 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Airway Obstruction / etiology Female Humans Lung / radiography Lung Volume Measurements Male Middle Aged Pulmonary Diffusing Capacity Respiratory Function Tests* Vital Capacity Wegener Granulomatosis / complications, pathology* |
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