Document Detail

Functional correlates of lung involvement in Wegener's granulomatosis. Use of pulmonary function tests in staging and follow-up.
MedLine Citation:
PMID:  7416186     Owner:  NLM     Status:  MEDLINE    
To examine the usefulness of pulmonary function testing in the clinical management of patients with Wegener's granulomatosis, 22 subjects with biopsy proved disease were evaluated using routine functional parameters. Although reduced lung volumes and diffusing capacity occurred frequently, the most common abnormality was in obstruction to airflow. Comparison of these functional parameters with roentgenographic and clinical findings revealed that reduced lung volumes were useful in detecting focal infiltrates, mass or cavitary lesions and diffuse interstitial involvement whereas airflow measurements were useful in detecting focal large airway lesions. In people with evidence of limitation of airflow, respiratory complications frequently developed in the form of acute tracheal obstruction of lobar collapse. In addition, serial evaluation of lung function during treatment revealed that although in most patients lung volumes and airflow obstruction improved or stabilized, a reduction of diffusing capacity was common. These studies suggest that routine pulmonary function testing may be a useful tool in the staging of patients with Wegener's granulomatosis and in following responses to therapy.
D M Rosenberg; S E Weinberger; J D Fulmer; M W Flye; A S Fauci; R G Crystal
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of medicine     Volume:  69     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1980-11-24     Completed Date:  1980-11-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  387-94     Citation Subset:  AIM; IM    
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MeSH Terms
Airway Obstruction / etiology
Lung / radiography
Lung Volume Measurements
Middle Aged
Pulmonary Diffusing Capacity
Respiratory Function Tests*
Vital Capacity
Wegener Granulomatosis / complications,  pathology*

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