Document Detail

Functional contributions of the plasma membrane calcium ATPase and the sodium-calcium exchanger at mouse parallel fibre to Purkinje neuron synapses.
MedLine Citation:
PMID:  23138229     Owner:  NLM     Status:  Publisher    
We investigated how two calcium clearance mechanisms, the sodium-calcium exchanger-NCX, and the plasma membrane calcium ATPase-PMCA2, function at the facilitating cerebellar parallel fibre to Purkinje neuron (PF-PN) synapse. Forward mode NCX helped recover PF presynaptic calcium elevations when the PFs received a double stimulation and the calcium load was sufficiently high. A smaller presynaptic calcium load evoked by a single PF stimulation failed to recruit NCX in wild-type mice but did so when PMCA2 was absent in PFs from PMCA2 knockout mice. Simulated calcium dynamics using a simple single-compartment model reported qualitatively similar effects. Functionally, reduced NCX activity in the absence of PMCA also prolonged the recovery of facilitation at the PF-PN synapse, beyond that seen by reduced NCX activity alone. We conclude that PMCA and NCX work in parallel to accurately shape residual presynaptic calcium recovery dynamics and fine-tune facilitation at this important cerebellar synapse.
Chris J Roome; Thomas Knöpfel; Ruth M Empson
Related Documents :
25315779 - Presynaptic control of glycine transporter 2 (glyt2) by physical and functional associa...
18970129 - Classification of aniseed drinks by means of cluster, linear discriminant analysis and ...
3742009 - Changes in urinary composition of calcium oxalate stone formers.
19857269 - Influence of the calcium concentration in the presence of organic phosphorus on the phy...
24671529 - Synaptic excitation is regulated by the postsynaptic dsk channel at the drosophila larv...
8842359 - Influence of carboxylate ions containing polymers on calcification: in vitro study.
20566409 - A-887826 is a structurally novel, potent and voltage-dependent na(v)1.8 sodium channel ...
8395619 - Mathematical modelling of the enteric nervous network. ii: facilitation and inhibition ...
1761969 - Q beta and q gamma components of intramembranous charge movement in frog cut twitch fib...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  Pflugers Archiv : European journal of physiology     Volume:  -     ISSN:  1432-2013     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Physiology, Brain Health Research Centre, University of Otago, PO Box 913, 9054, Dunedin, New Zealand.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inhibition of cyclin-dependent kinase 6 suppresses cell proliferation and enhances radiation sensiti...
Next Document:  Multiplexed visualization of dynamic signaling networks using genetically encoded fluorescent protei...