| Functional consequences of acute anterior vs. posterior wall ischemia in canine left ventricles. | |
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MedLine Citation:
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PMID: 3381894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We compared the consequences of acute anterior and posterior wall ischemia on regional left ventricular function in seven open-chest dogs. Circumferentially oriented sonomicrometers were implanted in the midwall of the anterior and posterior left ventricle. The left anterior descending (LAD) and left circumflex (LCX) coronary arteries were each occluded for 3 min, with 45 min of reperfusion between the two occlusions. The ischemic areas at risk, as assessed by postmortem perfusion techniques, were similar for anterior (34.5 +/- 12.5 g) and posterior (32.3 +/- 9.4 g) wall ischemia. Both occlusions produced a similar increase in end-diastolic pressure. After LAD occlusion, total segment shortening (end diastole to aortic valve closure) in the nonischemic posterior wall increased from 8.0 +/- 3.9 to 10.8 +/- 4.4%, solely caused by increased isovolumic shortening. In contrast, with LCX occlusion, total segment shortening in the nonischemic anterior wall increased significantly more, from 10.5 +/- 3.8 to 14.6 +/- 4.2% caused by nearly equal increases in isovolumic and ejection phase shortening. Thus, with both LAD and LCX occlusions, there was increased shortening in nonischemic areas during isovolumic systole, which was "wasted" in paradoxically stretching the ischemic zone. However, a compensatory increase in nonischemic area ejection phase shortening occurred only with LCX occlusions. These findings may explain the greater functional impairment that occurs with LAD than LCX occlusions. |
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Authors:
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B D Hoit; W Y Lew |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 254 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1988 Jun |
Date Detail:
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Created Date: 1988-07-15 Completed Date: 1988-07-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1065-73 Citation Subset: IM |
Affiliation:
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Department of Medicine, Veterans Administration Medical Center, San Diego, California. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Blood Pressure Coronary Disease / physiopathology* Dogs Heart / physiopathology* Heart Rate Heart Ventricles / physiopathology Reference Values Ventricular Function |
| Grant Support | |
ID/Acronym/Agency:
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HL-0173-01/HL/NHLBI NIH HHS; HL-07444/HL/NHLBI NIH HHS; HL-17682/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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