| Functional connectivity in the rat brain: a complex network approach. | |
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MedLine Citation:
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PMID: 20813478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Functional connectivity analyses of fMRI data can provide a wealth of information on the brain functional organization and have been widely applied to the study of the human brain. More recently, these methods have been extended to preclinical species, thus providing a powerful translational tool. Here, we review methods and findings of functional connectivity studies in the rat. More specifically, we focus on correlation analysis of pharmacological MRI (phMRI) responses, an approach that has enabled mapping the patterns of connectivity underlying major neurotransmitter systems in vivo. We also review the use of novel statistical approaches based on a network representation of the functional connectivity and their application to the study of the rat brain functional architecture. |
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Authors:
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Angelo Bifone; Alessandro Gozzi; Adam J Schwarz |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-09-01 |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 28 ISSN: 1873-5894 ISO Abbreviation: Magn Reson Imaging Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-24 Completed Date: 2011-01-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1200-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Italian Institute of Technology, Center for Nanotechnology Innovation, IIT@NEST, Piazza San Silvestro 12, Pisa, Italy. angelo.bifone@iit.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antidepressive Agents, Second-Generation / pharmacology Brain / drug effects, pathology* Brain Mapping / methods* Fluoxetine / pharmacology Image Processing, Computer-Assisted Magnetic Resonance Imaging / methods* Models, Neurological Models, Statistical Neural Pathways / physiology Neurotransmitter Agents / metabolism Rats Synaptic Transmission |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Second-Generation; 0/Neurotransmitter Agents; 54910-89-3/Fluoxetine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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