| Functional and clinical implications of cardiac resynchronization therapy on outcomes of diabetic patients with heart failure. | |
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MedLine Citation:
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PMID: 21139508 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIMS: To compare functional and structural changes of the left ventricle and long-term clinical outcomes in diabetic and nondiabetic patients with heart failure undergoing cardiac resynchronization therapy (CRT). METHODS: Sixty-eight patients with heart failure undergoing CRT were included: 18 were diabetic patients and 50 nondiabetic patients. The CRT eligibility was established by echocardiographic assessments. RESULTS: CRT improved ventricular geometry and dyssynchrony in both diabetic and nondiabetic patients, with no significant difference in the magnitude of the effects on the left ventricular function. Over a median follow-up of 30.6 ± 6.2 months, there were no significant differences in the rates of any cause death (16.7 vs. 14.0%, P = 0.72), cardiac death (11.1 vs. 8.0%, P = 0.65) and heart rehospitalization (5.6 vs. 6.0%, P = 1.0), between diabetic and nondiabetic patients, respectively. Diabetes was not found to be an independent factor associated with worse clinical outcome. CONCLUSION: Resynchronization therapy provided significant functional and hemodynamic improvements in both diabetic and nondiabetic patients. Long-term prognosis in heart failure patients with diabetes was comparable with that in those without diabetes. |
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Authors:
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Gloria Santangelo; Daniela Dugo; Massimiliano Mulè; Euglena Puzzangara; Vincenzo Schillaci; Salvatore Timineri; Piera Capranzano; Angelo Di Grazia; Claudio Liotta; Salvatore Scandura; Antonio Ragusa; Corrado Tamburino; Valeria Calvi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiovascular medicine (Hagerstown, Md.) Volume: 12 ISSN: 1558-2035 ISO Abbreviation: J Cardiovasc Med (Hagerstown) Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101259752 Medline TA: J Cardiovasc Med (Hagerstown) Country: United States |
Other Details:
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Languages: eng Pagination: 396-400 Citation Subset: IM |
Affiliation:
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Electrophysiology Unit, Cardiology Department, Ferrarotto Hospital, University of Catania, Catania, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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