| Functional chiral asymmetry in descending thoracic aorta. | |
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MedLine Citation:
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PMID: 2242523 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine whether rotational blood flow or chiral asymmetry exists in the human descending thoracic aorta, we established the ability of color Doppler ultrasound to detect rotational flow in a tornado tube model of a vortex descending fluid column. In a model of the human aortic arch with a pulse duplicator, color Doppler was then used to demonstrate that rotational flow occurs first in the transverse arch and then in the proximal descending thoracic aorta. With the use of color Doppler esophageal echocardiography, 53 patients (age range, 25-78 years; mean age, 56.4 years) were prospectively examined for rotational flow in the descending thoracic aorta. At 10 cm superior to retro-left ventricular position, 22 of 38 patients (58%) revealed rotational flow with obvious diastolic counterclockwise rotation but less obvious systolic clockwise rotation. At 5 cm superior to retro-left ventricular position, 29 of 46 patients (63%) revealed rotational flow with a tendency toward systolic clockwise and diastolic counterclockwise rotation. At the retro-left ventricular position, 47 of 53 patients (89%) revealed rotational flow, usually of a clockwise direction, occurring in systole. Our data suggest that aortic flow is not purely pulsatile and axial but has a rotational component. Rotational flow begins in the aortic arch and is carried through to the descending thoracic aorta, where flow is chirally asymmetric with systolic clockwise and diastolic counterclockwise components. These data demonstrate an aortic rotational flow component that may have physiological implications for organ perfusion. |
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Authors:
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L J Frazin; G Lanza; M Vonesh; F Khasho; C Spitzzeri; S McGee; D Mehlman; K B Chandran; J Talano; D McPherson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 82 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1990 Dec |
Date Detail:
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Created Date: 1991-01-03 Completed Date: 1991-01-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1985-94 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Northwestern University Medical School, Chicago, IL 60611. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aorta, Thoracic / physiology*, physiopathology Cardiovascular Diseases / physiopathology Echocardiography / methods Echocardiography, Doppler Esophagus Female Humans Male Middle Aged Models, Cardiovascular Regional Blood Flow Rotation |
| Grant Support | |
ID/Acronym/Agency:
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HL-27035-08/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment In:
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Circulation. 1990 Dec;82(6):2263-5
[PMID:
2242551
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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