Document Detail


Functional characterization of a supramolecular affinity switch at the single molecule level.
MedLine Citation:
PMID:  22009325     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Surface-immobilized and switchable resorcin[4]arene receptor molecules were quantitatively investigated with atomic force microscopy (AFM) and AFM-single molecule force spectroscopy (AFM-SMFS). The upper rim of the supramolecular receptor cavities was modified with two photodimerizable anthracene moieties. The molecular constitution can be externally switched and controlled by exposure to ultraviolet (UV) light and heat. The topography as well as the complexation affinity against small ammonium guest ions of the two isomers were investigated at the single molecule level. Our results demonstrate the feasibility to externally control the supramolecular receptor's affinity and simultaneously quantify and associate these binding properties with the structural change of the resorcin[4]arenes structure on the basis of the measured molecule corrugation height.
Authors:
Volker Walhorn; Christian Schäfer; Tobias Schröder; Jochen Mattay; Dario Anselmetti
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-18
Journal Detail:
Title:  Nanoscale     Volume:  -     ISSN:  2040-3372     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101525249     Medline TA:  Nanoscale     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Experimental Biophysics and Applied Nanoscience, Department of Physics, Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany. dario.anselmetti@physik.uni-bielefeld.de.
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