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Functional characterization of isolated, perfused outer medullary descending human vasa recta.
MedLine Citation:
PMID:  23414239     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: The renal medulla plays an important role in the control of water and salt balance by the kidney. Outer medullary descending vasa recta (OMDVR) are microscopic vessels providing blood flow to the renal medulla. Data on the physiology of human vasa recta are scarce. Therefore we established an experimental model of human single isolated perfused OMDVR, and characterized their vasoactivity in response to angiotensin II and to pressure changes. Methods: Human non-malignant renal tissue was obtained from patients undergoing nephrectomy due to renal cell carcinoma. OMDVR were dissected under magnification and perfused using concentric microscopic pipettes. The response of OMDVR to angiotensin II and pressure changes was quantified in serial pictures. All patients signed a consent form prior to surgery. Results: OMDVR constricted significantly after bolus applications of angiotensin II. OMDVR constriction to angiotensin II was also concentration dependent. Response to luminal pressure changes were different according to the diameter of vessels, with larger OMDVR constricting after pressure increase, while smaller ones did not. Conclusion: OMDVR constrict in response to angiotensin II and pressure increases. Our results show that OMDVR may take part in the regulation of medullary blood flow in humans. Our model may be suitable for investigating disturbances of renal medullary circulation in human subjects. Acta Physiologica © 2013 Scandinavian Physiological Society.
Authors:
Mauricio M Sendeski; Zhi Zhao Liu; Andrea Perlewitz; Jonas F Busch; Odiljon Ikromov; Steffen Weikert; Pontus B Persson; Andreas Patzak
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-15
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  -     ISSN:  1748-1716     ISO Abbreviation:  Acta Physiol (Oxf)     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Acta Physiologica © 2013 Scandinavian Physiological Society.
Affiliation:
Institut für Vegetative Physiologie, Charité Universitätsmedizin-Berlin, Berlin, Germany.
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