Document Detail


Functional characterization of the extraclassical receptive field in macaque V1: contrast, orientation, and temporal dynamics.
MedLine Citation:
PMID:  23554504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neurons in primary visual cortex, V1, very often have extraclassical receptive fields (eCRFs). The eCRF is defined as the region of visual space where stimuli cannot elicit a spiking response but can modulate the response of a stimulus in the classical receptive field (CRF). We investigated the dependence of the eCRF on stimulus contrast and orientation in macaque V1 cells for which the laminar location was determined. The eCRF was more sensitive to contrast than the CRF across the whole population of V1 cells with the greatest contrast differential in layer 2/3. We confirmed that many V1 cells experience stronger suppression for collinear than orthogonal stimuli in the eCRF. Laminar analysis revealed that the predominant bias for collinear suppression was found in layers 2/3 and 4b. The laminar pattern of contrast and orientation dependence suggests that eCRF suppression may derive from different neural circuits in different layers, and may be comprised of two distinct components: orientation-tuned and untuned suppression. On average tuned suppression was delayed by ∼25 ms compared with the onset of untuned suppression. Therefore, response modulation by the eCRF develops dynamically and rapidly in time.
Authors:
Christopher A Henry; Siddhartha Joshi; Dajun Xing; Robert M Shapley; Michael J Hawken
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  33     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-04     Completed Date:  2013-05-28     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6230-42     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology
Animals
Brain Mapping*
Contrast Sensitivity / physiology*
Electrolysis
Macaca fascicularis
Male
Models, Neurological
Neural Inhibition / physiology
Neurons / physiology*
Nonlinear Dynamics
Orientation / physiology*
Photic Stimulation
Reaction Time
Visual Cortex / cytology*,  injuries,  physiology
Visual Fields / physiology*
Grant Support
ID/Acronym/Agency:
EY01472/EY/NEI NIH HHS; EY08300/EY/NEI NIH HHS; P30 EY013079/EY/NEI NIH HHS; R01 EY001472/EY/NEI NIH HHS; R01 EY008300/EY/NEI NIH HHS
Comments/Corrections

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