Document Detail

Functional characterization of chimpanzee cytomegalovirus chemokine, vCXCL-1(CCMV).
MedLine Citation:
PMID:  17433398     Owner:  NLM     Status:  MEDLINE    
Human cytomegaloviruses (HCMVs) are important pathogens in immunocompromised patients and newborns. The viral chemokine, vCXCL-1, of the Toledo (Tol) strain of HCMV has been implicated in HCMV virulence. Chimpanzee CMV (CCMV) has several genes with similarity to the vCXCL-1(Tol) gene, UL146. In order to test whether the CCMV viral chemokine, vCXCL-1(CCMV), is similar to vCXCL-1(Tol), we characterized its function in vitro. Receptor binding, activation, chemotaxis, signaling, and apoptosis in neutrophils were compared between vCXCL-1(Tol) and vCXCL-1(CCMV) and host chemokines. Although the homologues had similar activation potentials, chemotactic properties, and signaling, vCXCL-1(CCMV) had a approximately 70-fold lower affinity for CXCR2 and displayed differences in integrin upregulation and neutrophil apoptosis. These data demonstrate that in spite of extensive amino acid variability in vCXCL-1, CCMV may provide a model for assessing the role of vCXCL-1 in CMV pathogenesis in vivo.
Mindy Miller-Kittrell; Jiqing Sai; Mark Penfold; Ann Richmond; Tim E Sparer
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-04-11
Journal Detail:
Title:  Virology     Volume:  364     ISSN:  0042-6822     ISO Abbreviation:  Virology     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-06-11     Completed Date:  2007-08-01     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  0110674     Medline TA:  Virology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  454-65     Citation Subset:  IM    
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MeSH Terms
Amino Acid Sequence
Antigens, CD11b / metabolism
Antigens, CD11c / metabolism
Baculoviridae / genetics
Calcium Signaling
Chemokines, CXC / chemistry,  genetics*,  physiology*
Conserved Sequence
Cytomegalovirus / genetics*,  immunology*,  pathogenicity
Molecular Sequence Data
Neutrophils / immunology,  pathology,  virology
Pan troglodytes / immunology,  virology*
Protein Sorting Signals / genetics
Receptors, Interleukin-8B / physiology
Sequence Homology, Amino Acid
Viral Proteins / chemistry,  genetics*,  immunology,  physiology*
Virulence / genetics,  immunology
Grant Support
CA34590/CA/NCI NIH HHS; R01 CA034590/CA/NCI NIH HHS; R01 CA034590-24/CA/NCI NIH HHS
Reg. No./Substance:
0/Antigens, CD11b; 0/Antigens, CD11c; 0/Chemokines, CXC; 0/ITGAM protein, human; 0/Protein Sorting Signals; 0/Receptors, Interleukin-8B; 0/Viral Proteins

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