| Functional characterization of chimpanzee cytomegalovirus chemokine, vCXCL-1(CCMV). | |
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MedLine Citation:
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PMID: 17433398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human cytomegaloviruses (HCMVs) are important pathogens in immunocompromised patients and newborns. The viral chemokine, vCXCL-1, of the Toledo (Tol) strain of HCMV has been implicated in HCMV virulence. Chimpanzee CMV (CCMV) has several genes with similarity to the vCXCL-1(Tol) gene, UL146. In order to test whether the CCMV viral chemokine, vCXCL-1(CCMV), is similar to vCXCL-1(Tol), we characterized its function in vitro. Receptor binding, activation, chemotaxis, signaling, and apoptosis in neutrophils were compared between vCXCL-1(Tol) and vCXCL-1(CCMV) and host chemokines. Although the homologues had similar activation potentials, chemotactic properties, and signaling, vCXCL-1(CCMV) had a approximately 70-fold lower affinity for CXCR2 and displayed differences in integrin upregulation and neutrophil apoptosis. These data demonstrate that in spite of extensive amino acid variability in vCXCL-1, CCMV may provide a model for assessing the role of vCXCL-1 in CMV pathogenesis in vivo. |
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Authors:
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Mindy Miller-Kittrell; Jiqing Sai; Mark Penfold; Ann Richmond; Tim E Sparer |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-04-11 |
Journal Detail:
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Title: Virology Volume: 364 ISSN: 0042-6822 ISO Abbreviation: Virology Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-06-11 Completed Date: 2007-08-01 Revised Date: 2011-05-05 |
Medline Journal Info:
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Nlm Unique ID: 0110674 Medline TA: Virology Country: United States |
Other Details:
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Languages: eng Pagination: 454-65 Citation Subset: IM |
Affiliation:
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Department of Microbiology, University of Tennessee, Walters Life Sciences Rm F417, Knoxville, TN 37996, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Antigens, CD11b / metabolism Antigens, CD11c / metabolism Apoptosis Baculoviridae / genetics Calcium Signaling Chemokines, CXC / chemistry, genetics*, physiology* Conserved Sequence Cytomegalovirus / genetics*, immunology*, pathogenicity Humans Molecular Sequence Data Neutrophils / immunology, pathology, virology Pan troglodytes / immunology, virology* Protein Sorting Signals / genetics Receptors, Interleukin-8B / physiology Sequence Homology, Amino Acid Viral Proteins / chemistry, genetics*, immunology, physiology* Virulence / genetics, immunology |
| Grant Support | |
ID/Acronym/Agency:
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CA34590/CA/NCI NIH HHS; R01 CA034590-24/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD11b; 0/Antigens, CD11c; 0/Chemokines, CXC; 0/ITGAM protein, human; 0/Protein Sorting Signals; 0/Receptors, Interleukin-8B; 0/Viral Proteins |
| Comments/Corrections | |
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