Document Detail


Functional characteristics of L-glutamate, N-methyl-D-aspartate and kainate receptors in isolated brain synaptic membranes.
MedLine Citation:
PMID:  6095128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
L-Glutamic acid (L-Glu) and other excitatory amino acids and amino acid analogs enhanced [35S]thiocyanate (SCN-) uptake in isolated-resealed synaptic membrane vesicles. The SCN- uptake was used as a measure of membrane depolarization to evaluate the characteristics of functional excitatory amino acid receptors in the synaptic membranes. N-Methyl-D-aspartate (NMDA) and L-Glu produced additive effects on SCN- accumulation indicating the presence of distinct L-Glu and NMDA receptors. On the other hand, kainic acid (KA) and L-Glu shared either common receptor sites or ion channels. The effects of antagonists on NMDA, L-Glu, and KA stimulation of SCN- influx were consistent with previously reported electrophysiologic observations in intact neurons.
Authors:
H H Chang; E K Michaelis; S Roy
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurochemical research     Volume:  9     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1985-01-03     Completed Date:  1985-01-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  903-15     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / physiology*
Cell Membrane Permeability
Male
Membrane Potentials
Rats
Receptors, Glutamate
Receptors, Kainic Acid
Receptors, N-Methyl-D-Aspartate
Receptors, Neurotransmitter / physiology*
Synaptic Membranes / physiology*
Thiocyanates / metabolism
Grant Support
ID/Acronym/Agency:
AA 04732/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Glutamate; 0/Receptors, Kainic Acid; 0/Receptors, N-Methyl-D-Aspartate; 0/Receptors, Neurotransmitter; 0/Thiocyanates; 302-04-5/thiocyanate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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