| Functional changes in platelets during extracorporeal circulation. | |
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MedLine Citation:
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PMID: 237494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An in vitro trauma test was conducted to determine the effects of extracorporeal circulation on platelet count and function. Fresh human blood was circulated in two identical in vitro circuits for six hours at a rate of 500 ml per minute (500 recirculations). One circuit included a G.E.--Peirce membrane lung and the other was a control. Platelet aggregation induced by adenosine diphosphate (ADP), epinephrine, or collagen was studied before and after six hours of perfusion. No important drop in platelet count occurred in the control circuit (Control-C) following bypass, but there was a 20% drop for the lung circuit (Lung-C). Platelet aggregation was reduced by about 30% for the control circuit and 65% for the lung circuit. The large decrease in platelet function accompanied by only a moderate decrease in platelet count is discussed in terms of loss of the youngest and most active platelets, platelet inhibition due to ADP released by red blood cell lysis, and platelet trauma. |
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Authors:
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Y Tamari; L Aledort; E Puszkin; T J Degnan; N Wagner; M J Kaplitt; E C Peirce |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 19 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1975 Jun |
Date Detail:
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Created Date: 1975-09-09 Completed Date: 1975-09-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 639-47 Citation Subset: AIM; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Diphosphate
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pharmacology Blood Cell Count Blood Platelet Disorders / etiology Blood Platelets* Cell Survival Collagen / pharmacology Epinephrine / pharmacology Extracorporeal Circulation / adverse effects* Hemoglobins / analysis Hemolysis Humans Hydrogen-Ion Concentration Oxygenators, Membrane / adverse effects* Platelet Adhesiveness* Platelet Aggregation* / drug effects Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 51-43-4/Epinephrine; 58-64-0/Adenosine Diphosphate; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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