Document Detail

Functional capacity in patients with congestive heart failure.
MedLine Citation:
PMID:  10997747     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Six-minute walk distance (6MWd) is related to activities of daily living and is also an independent predictor of prognosis in patients with congestive heart failure (CHF). Therefore, it is important to determine factors that contribute to the variability of this test. METHODS AND RESULTS: We assessed the relationship between 6MWd and peak aerobic capacity (VO2) and dynamic muscle strength in 180 patients with CHF (age, 66+/-10 years; 146 men, 34 women; ejection fraction, .29+/-0.08). We also hypothesized that a measure of work performed during the walk test (6MWw) would be a better indicator of exercise capacity than 6MWd. The 6MWd had weak to moderate correlations with dynamic muscle strength (r = 0.33 to 0.41) and peak VO2 (r = 0.48). However, 6MWw was strongly related to dynamic muscle strength (r = 0.63 to 0.70) and peak VO2 (r = 0.77). Multivariate analysis indicated that a model combining dynamic muscle strength and peak VO2 explained 69% of the variance in 6MWw, more than with peak VO2 alone (R2 = 0.59). CONCLUSIONS: Compared with 6MWd, 6MWw correlates significantly better with peak VO2 and dynamic muscle strength, suggesting that 6MWw may be a better reflection of a patient's exercise capacity. Furthermore, these results suggest that an exercise program combining both aerobic and strength training in patients with CHF may improve 6MWw and therefore 6MWd.
M C Hendrican; R S McKelvie; T Smith; N McCartney; J Pogue; K K Teo; S Yusuf
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  6     ISSN:  1071-9164     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2001-01-09     Completed Date:  2001-01-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  214-9     Citation Subset:  IM    
Department of Medicine, Hamilton Civic Hospitals Research Centre, Hamilton General Hospital, McMaster University, Ontario, Canada.
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MeSH Terms
Cross-Sectional Studies
Exercise Test / methods
Exercise Tolerance*
Heart Failure / diagnosis*,  metabolism,  physiopathology*
Middle Aged
Multivariate Analysis
Muscle Contraction
Muscle, Skeletal / physiopathology*
Oxygen Consumption*
Predictive Value of Tests
Severity of Illness Index
Stroke Volume*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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