Document Detail


Functional brain imaging in pure akinesia with gait freezing: [18F] FDG PET and [18F] FP-CIT PET analyses.
MedLine Citation:
PMID:  18951539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pure akinesia with gait freezing (PAGF) has characteristic features, including freezing of gait and prominent speech disturbance without rigidity or tremor. The purpose of this study was to investigate changes in brain glucose metabolism and presynaptic dopaminergic function in PAGF. By using [(18)F] fluorodeoxyglucose (FDG) PET, 11 patients with PAGF were compared with 14 patients with probable progressive supranuclear palsy (PSP), 13 patients with Parkinson's disease (PD), and 11 normal controls. [(18)F] N-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane (FP-CIT) PET was performed in 11 patients with PAGF and with 10 normal controls. The PAGF patients showed decreased glucose metabolism in the midbrain when compared with normal controls. PSP patients showed a similar topographic distribution of glucose hypometabolism with additional areas, including the frontal cortex, when compared with normal controls. The FP-CIT PET findings in patients with PAGF revealed severely decreased uptake bilaterally in the basal ganglia. These findings suggest that both PAGF and PSP may be part of the same pathophysiologic spectrum of disease. However, the reason why PAGF manifests clinically in a different manner needs to be further elucidated.
Authors:
Hee K Park; Jae S Kim; Ki C Im; Seung J Oh; Mi J Kim; Jae-Hong Lee; Sun J Chung; Myoung C Lee
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  24     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-06-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  237-45     Citation Subset:  IM    
Affiliation:
Department of Neurology, Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Basal Ganglia Diseases / complications,  metabolism,  radionuclide imaging*
Brain / metabolism,  pathology,  radionuclide imaging*
Carbon Radioisotopes / diagnostic use
Female
Fluorine Radioisotopes / diagnostic use
Fluorodeoxyglucose F18 / diagnostic use
Gait Disorders, Neurologic / etiology,  metabolism,  radionuclide imaging*
Glucose / metabolism
Humans
Hypokinesia / etiology,  metabolism,  radionuclide imaging*
Iodine Radioisotopes / diagnostic use
Magnetic Resonance Imaging
Male
Mesencephalon / metabolism,  radionuclide imaging
Middle Aged
Parkinson Disease / complications,  radionuclide imaging*
Positron-Emission Tomography*
Radiopharmaceuticals / diagnostic use
Supranuclear Palsy, Progressive / complications,  radionuclide imaging*
Tropanes / diagnostic use
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Fluorine Radioisotopes; 0/Iodine Radioisotopes; 0/Radiopharmaceuticals; 0/Tropanes; 155797-99-2/2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; 50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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