| Functional brain imaging in pure akinesia with gait freezing: [18F] FDG PET and [18F] FP-CIT PET analyses. | |
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MedLine Citation:
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PMID: 18951539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pure akinesia with gait freezing (PAGF) has characteristic features, including freezing of gait and prominent speech disturbance without rigidity or tremor. The purpose of this study was to investigate changes in brain glucose metabolism and presynaptic dopaminergic function in PAGF. By using [(18)F] fluorodeoxyglucose (FDG) PET, 11 patients with PAGF were compared with 14 patients with probable progressive supranuclear palsy (PSP), 13 patients with Parkinson's disease (PD), and 11 normal controls. [(18)F] N-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane (FP-CIT) PET was performed in 11 patients with PAGF and with 10 normal controls. The PAGF patients showed decreased glucose metabolism in the midbrain when compared with normal controls. PSP patients showed a similar topographic distribution of glucose hypometabolism with additional areas, including the frontal cortex, when compared with normal controls. The FP-CIT PET findings in patients with PAGF revealed severely decreased uptake bilaterally in the basal ganglia. These findings suggest that both PAGF and PSP may be part of the same pathophysiologic spectrum of disease. However, the reason why PAGF manifests clinically in a different manner needs to be further elucidated. |
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Authors:
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Hee K Park; Jae S Kim; Ki C Im; Seung J Oh; Mi J Kim; Jae-Hong Lee; Sun J Chung; Myoung C Lee |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 24 ISSN: 1531-8257 ISO Abbreviation: Mov. Disord. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-02-02 Completed Date: 2009-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: United States |
Other Details:
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Languages: eng Pagination: 237-45 Citation Subset: IM |
Affiliation:
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Department of Neurology, Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Basal Ganglia Diseases / complications, metabolism, radionuclide imaging* Brain / metabolism, pathology, radionuclide imaging* Carbon Radioisotopes / diagnostic use Female Fluorine Radioisotopes / diagnostic use Fluorodeoxyglucose F18 / diagnostic use Gait Disorders, Neurologic / etiology, metabolism, radionuclide imaging* Glucose / metabolism Humans Hypokinesia / etiology, metabolism, radionuclide imaging* Iodine Radioisotopes / diagnostic use Magnetic Resonance Imaging Male Mesencephalon / metabolism, radionuclide imaging Middle Aged Parkinson Disease / complications, radionuclide imaging* Positron-Emission Tomography* Radiopharmaceuticals / diagnostic use Supranuclear Palsy, Progressive / complications, radionuclide imaging* Tropanes / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Fluorine Radioisotopes; 0/Iodine Radioisotopes; 0/Radiopharmaceuticals; 0/Tropanes; 155797-99-2/2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; 50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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