Document Detail


Functional brain basis of hypnotizability.
MedLine Citation:
PMID:  23026956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Focused hypnotic concentration is a model for brain control over sensation and behavior. Pain and anxiety can be effectively alleviated by hypnotic suggestion, which modulates activity in brain regions associated with focused attention, but the specific neural network underlying this phenomenon is not known.
OBJECTIVE: To investigate the brain basis of hypnotizability.
DESIGN: Cross-sectional, in vivo neuroimaging study performed from November 2005 through July 2006.
SETTING: Academic medical center at Stanford University School of Medicine.
PATIENTS: Twelve adults with high and 12 adults with low hypnotizability.
MAIN OUTCOME MEASURES: Functional magnetic resonance imaging to measure functional connectivity networks at rest, including default-mode, salience, and executive-control networks; structural T1 magnetic resonance imaging to measure regional gray and white matter volumes; and diffusion tensor imaging to measure white matter microstructural integrity.
RESULTS: High compared with low hypnotizable individuals had greater functional connectivity between the left dorsolateral prefrontal cortex, an executive-control region of the brain, and the salience network composed of the dorsal anterior cingulate cortex, anterior insula, amygdala, and ventral striatum, involved in detecting, integrating, and filtering relevant somatic, autonomic, and emotional information using independent component analysis. Seed-based analysis confirmed elevated functional coupling between the dorsal anterior cingulate cortex and the dorsolateral prefrontal cortex in high compared with low hypnotizable individuals. These functional differences were not due to any variation in brain structure in these regions, including regional gray and white matter volumes and white matter microstructure.
CONCLUSIONS: Our results provide novel evidence that altered functional connectivity in the dorsolateral prefrontal cortex and dorsal anterior cingulate cortex may underlie hypnotizability. Future studies focusing on how these functional networks change and interact during hypnosis are warranted.
Authors:
Fumiko Hoeft; John D E Gabrieli; Susan Whitfield-Gabrieli; Brian W Haas; Roland Bammer; Vinod Menon; David Spiegel
Related Documents :
15569896 - Regional brain activity in women grieving a romantic relationship breakup.
19176826 - Connectivity-based parcellation of human cingulate cortex and its relation to functiona...
11160446 - Amygdala regulation of nucleus accumbens dopamine output is governed by the prefrontal ...
6983696 - Elimination of medial prefrontal cortex self-stimulation following transection of effer...
20926666 - Differential patterns of inputs create functional zones in central nucleus of inferior ...
23364746 - Genetic identification of c fibres that detect massage-like stroking of hairy skin in v...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  69     ISSN:  1538-3636     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-02     Completed Date:  2012-12-13     Revised Date:  2014-04-16    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1064-72     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Brain Mapping
Cerebral Cortex / physiology*
Cross-Sectional Studies
Diffusion Tensor Imaging / instrumentation,  methods*
Executive Function / classification,  physiology*
Female
Gyrus Cinguli / physiology
Humans
Hypnosis*
Magnetic Resonance Imaging / instrumentation,  methods*
Male
Nerve Net / physiology*
Prefrontal Cortex / physiology
Young Adult
Grant Support
ID/Acronym/Agency:
P41 RR009784/RR/NCRR NIH HHS; P41-EB015891/EB/NIBIB NIH HHS; RC1 AT0005733/AT/NCCAM NIH HHS
Comments/Corrections
Erratum In:
Arch Gen Psychiatry. 2013 Jan;70(1):97

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The associations of insomnia with costly workplace accidents and errors: results from the america in...
Next Document:  Twenty-year depressive trajectories among older women.